Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid-liquid interface area

Xuan Mu, Qionglin Liang*, Ping Hu, Kangning REN, Yiming Wang, Guoan Luo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Radix Salvia Miltiorrhiza, a famous herb medicine is widely used in China and limitedly used in USA, Japan, and other countries for the treatment of cardiovascular and cerebrovascular diseases. This herb medicine has two groups (non-polar and polar) of active ingredients with distinct clinical effects, and thus theses ingredients should be separately used to enhance therapeutic efficacy and reduce side effect. In this article, as an alternative of conventional mechanical shaking and separatory funnel, laminar flow extraction in microfluidic chip is proposed to separate the two kinds of herb ingredients. Compared with conventional methods, microfluidic chip provides continuous extraction, less labor intensity, and better performance. Furthermore, we employ three-phase laminar flow to provide double liquid-liquid interface area, circumventing the low efficiency of two-phase laminar flow. Therefore, the extraction ratio is dramatically improved to 92% (tanshinone IIA). To predict the extraction ratio, a straightforward theoretical model is also established and agrees well with the experimental results. This microfluidic chip would be a powerful technical platform for handling complicated natural products.

Original languageEnglish
Pages (from-to)365-373
Number of pages9
JournalMicrofluidics and Nanofluidics
Volume9
Issue number2-3
DOIs
Publication statusPublished - Aug 2010

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

User-Defined Keywords

  • Hydrophobic modification
  • Laminar flow
  • Microfluidics
  • Radix Salvia Miltiorrhiza
  • Solvent extraction

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