Selective detection of sulfide in human lung cancer cells with a blue-fluorescent “ON-OFF-ON” benzimidazole-based chemosensor ensemble

Chak Shing Kwan, Tao Wang, Sing Ming Chan, Zongwei CAI*, Ken C F LEUNG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A completely water-soluble, high quantum yield blue-fluorescent benzimidazole derivative (AQ), containing a rigid benzimidazole-thiophene structure, was synthesized. Among 21 metal ions, the fluorescence ofAQwas selectively turned off by Cu2+to form anAQ-Cu2+ensemble. Thereafter, the fluorescence of theAQ-Cu2+ensemble was turned on by sulfide (S2-) with high selectivity and sensitivity in pure water solution. In comparison withAQ-Ag+andAQ-Hg2+ensembles,AQ-Cu2+was the only ensemble that was capable of detecting a sulfide anion. Also, the fluorescence intensity ofAQwas linearly proportional to the concentration of Cu2+and S2-. Both Cu2+and S2-were detected within a minutein vitro. Moreover,AQworked best in the pH range of 5-10 and had a limit of detection of 50 nM and 354 nM for Cu2+and S2-respectively. It was employed for the detection of sulfide in human lung cancer A549 cells with low cytotoxicity.

Original languageEnglish
Pages (from-to)5445-5453
Number of pages9
JournalDalton Transactions
Volume49
Issue number17
DOIs
Publication statusPublished - 7 May 2020

Scopus Subject Areas

  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Selective detection of sulfide in human lung cancer cells with a blue-fluorescent “ON-OFF-ON” benzimidazole-based chemosensor ensemble'. Together they form a unique fingerprint.

Cite this