Selective autophagy: The new player in the fight against neurodegenerative diseases?

Ming Yue Wu, Juxian SONG, Sheng Fang Wang, Cui Zan Cai, Min LI*, Jia Hong Lu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading organelles, invading pathogens and protein aggregates. Recent studies have revealed an intrinsic connection between selective autophagy and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Given the vital roles of selective autophagy in these neurodegenerative diseases, modulation of this process is emerging as a new therapeutic strategy for neuroprotection. This review introduces the concept of selective autophagy, provides an overview of the pathological connection between selective autophagy and neurodegenerative diseases, and discusses approaches to modulate selective autophagy for therapeutic effects against neurodegenerative diseases.

Original languageEnglish
Pages (from-to)79-90
Number of pages12
JournalBrain Research Bulletin
Volume137
DOIs
Publication statusPublished - Mar 2018

Scopus Subject Areas

  • Neuroscience(all)

User-Defined Keywords

  • Aggrephagy
  • Chaperone-mediated autophagy
  • Mitophagy
  • Neurodegenerative diesease
  • Selective autophagy

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