TY - JOUR
T1 - Selective autophagy
T2 - The new player in the fight against neurodegenerative diseases?
AU - Wu, Ming-Yue
AU - Song, Ju-Xian
AU - Wang, Sheng-Fang
AU - Cai, Cui-Zan
AU - Li, Min
AU - Lu, Jia-Hong
N1 - Funding Information:
This study was supported by Grants of NSFC-31500831, EF001/ICMS-LJH/2015/HKBU, SKL-QRCM-2014-2016, FDCT-022/2015/A1, FDCT-092-2015-A3 and MYRG2016-00119-ICMS-QRCM (to Jiahong Lu) and the grants of RGC/HKBU-121009/14, HMRF12132091, RC-IRMS/15-16/04, FRG I/15-16/042 and FRG II/15-16/034 (to Min Li).
Publisher copyright:
© 2017 Elsevier Inc. All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading organelles, invading pathogens and protein aggregates. Recent studies have revealed an intrinsic connection between selective autophagy and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Given the vital roles of selective autophagy in these neurodegenerative diseases, modulation of this process is emerging as a new therapeutic strategy for neuroprotection. This review introduces the concept of selective autophagy, provides an overview of the pathological connection between selective autophagy and neurodegenerative diseases, and discusses approaches to modulate selective autophagy for therapeutic effects against neurodegenerative diseases.
AB - Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading organelles, invading pathogens and protein aggregates. Recent studies have revealed an intrinsic connection between selective autophagy and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Given the vital roles of selective autophagy in these neurodegenerative diseases, modulation of this process is emerging as a new therapeutic strategy for neuroprotection. This review introduces the concept of selective autophagy, provides an overview of the pathological connection between selective autophagy and neurodegenerative diseases, and discusses approaches to modulate selective autophagy for therapeutic effects against neurodegenerative diseases.
KW - Aggrephagy
KW - Chaperone-mediated autophagy
KW - Mitophagy
KW - Neurodegenerative diesease
KW - Selective autophagy
UR - http://www.scopus.com/inward/record.url?scp=85034613492&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2017.11.009
DO - 10.1016/j.brainresbull.2017.11.009
M3 - Review article
C2 - 29155260
AN - SCOPUS:85034613492
SN - 0361-9230
VL - 137
SP - 79
EP - 90
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -