Secondary metabolites from Andrographis paniculata

Wenkui Li, Xudong Xu, Hongjie Zhang, Cuiying Ma, Harry Fong, Richard Van Breemen, John Fitzloff*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

79 Citations (Scopus)

Abstract

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2007

Scopus Subject Areas

  • Chemistry(all)
  • Drug Discovery

User-Defined Keywords

  • Andrographis paniculata
  • Cytotoxicity
  • Diterpenoid
  • Flavonoid
  • LC-MS/MS
  • Secondary metabolite

Fingerprint

Dive into the research topics of 'Secondary metabolites from Andrographis paniculata'. Together they form a unique fingerprint.

Cite this