TY - JOUR
T1 - Secondary metabolites from Andrographis paniculata
AU - Li, Wenkui
AU - Xu, Xudong
AU - Zhang, Hongjie
AU - Ma, Cuiying
AU - Fong, Harry
AU - Van Breemen, Richard
AU - Fitzloff, John
PY - 2007/3
Y1 - 2007/3
N2 - Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.
AB - Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.
KW - Andrographis paniculata
KW - Cytotoxicity
KW - Diterpenoid
KW - Flavonoid
KW - LC-MS/MS
KW - Secondary metabolite
UR - http://www.scopus.com/inward/record.url?scp=34047146431&partnerID=8YFLogxK
U2 - 10.1248/cpb.55.455
DO - 10.1248/cpb.55.455
M3 - Journal article
C2 - 17329890
AN - SCOPUS:34047146431
SN - 0009-2363
VL - 55
SP - 455
EP - 458
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 3
ER -