Secondary metabolites from Andrographis paniculata

Wenkui Li; Xudong Xu; Hongjie Zhang; Cuiying Ma; Harry Fong; Richard Van Breemen; John Fitzloff

doi:10.1248/cpb.55.455

Secondary metabolites from Andrographis paniculata

Wenkui Li, Xudong Xu, Hongjie Zhang, Cuiying Ma, Harry Fong, Richard Van Breemen, John Fitzloff^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

80 Citations (Scopus)

Abstract

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED₅₀ values of 6.5 and 5.1 μg/ml, respectively.

Original language	English
Pages (from-to)	455-458
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	3
DOIs	https://doi.org/10.1248/cpb.55.455
Publication status	Published - Mar 2007

Scopus Subject Areas

General Chemistry
Drug Discovery

User-Defined Keywords

Andrographis paniculata
Cytotoxicity
Diterpenoid
Flavonoid
LC-MS/MS
Secondary metabolite

Access to Document

10.1248/cpb.55.455

Cite this

@article{e56819a5d7d04674b771aee91abb8e92,

title = "Secondary metabolites from Andrographis paniculata",

abstract = "Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.",

keywords = "Andrographis paniculata, Cytotoxicity, Diterpenoid, Flavonoid, LC-MS/MS, Secondary metabolite",

author = "Wenkui Li and Xudong Xu and Hongjie Zhang and Cuiying Ma and Harry Fong and {Van Breemen}, Richard and John Fitzloff",

year = "2007",

month = mar,

doi = "10.1248/cpb.55.455",

language = "English",

volume = "55",

pages = "455--458",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "3",

}

TY - JOUR

T1 - Secondary metabolites from Andrographis paniculata

AU - Li, Wenkui

AU - Xu, Xudong

AU - Zhang, Hongjie

AU - Ma, Cuiying

AU - Fong, Harry

AU - Van Breemen, Richard

AU - Fitzloff, John

PY - 2007/3

Y1 - 2007/3

N2 - Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.

AB - Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O- β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy- flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.

KW - Andrographis paniculata

KW - Cytotoxicity

KW - Diterpenoid

KW - Flavonoid

KW - LC-MS/MS

KW - Secondary metabolite

UR - http://www.scopus.com/inward/record.url?scp=34047146431&partnerID=8YFLogxK

U2 - 10.1248/cpb.55.455

DO - 10.1248/cpb.55.455

M3 - Journal article

C2 - 17329890

AN - SCOPUS:34047146431

SN - 0009-2363

VL - 55

SP - 455

EP - 458

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 3

ER -

Secondary metabolites from Andrographis paniculata

Abstract

Scopus Subject Areas

User-Defined Keywords

Access to Document

Other files and links

Fingerprint

Cite this