Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Li-mei Li, Guo-You Li, Li-sheng Ding, Chun Lei, Li-bin Yang, Yong Zhao, Zhi-ying Weng, Sheng-hong Li, Sheng-xiong Huang, Wei-lie Xiao, Simon Quan-Bin HAN, Han-dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

23 Citations (Scopus)

Abstract

Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.
Original languageEnglish
Pages (from-to)9100-9103
JournalTetrahedron Letters
Volume48
Issue number52
DOIs
Publication statusPublished - 24 Dec 2007

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