Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Li-mei Li; Guo-You Li; Li-sheng Ding; Chun Lei; Li-bin Yang; Yong Zhao; Zhi-ying Weng; Sheng-hong Li; Sheng-xiong Huang; Wei-lie Xiao; Simon Quan-Bin HAN; Han-dong Sun

doi:10.1016/j.tetlet.2007.10.133

Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Li-mei Li, Guo-You Li, Li-sheng Ding, Chun Lei, Li-bin Yang, Yong Zhao, Zhi-ying Weng, Sheng-hong Li, Sheng-xiong Huang, Wei-lie Xiao, Simon Quan-Bin HAN, Han-dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

24 Citations (Scopus)

Abstract

Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.

Original language	English
Pages (from-to)	9100-9103
Journal	Tetrahedron Letters
Volume	48
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2007.10.133
Publication status	Published - 24 Dec 2007

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10.1016/j.tetlet.2007.10.133

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@article{feb2c775e60649e8a43a0848937f085e,

title = "Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus",

abstract = "Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.",

author = "Li-mei Li and Guo-You Li and Li-sheng Ding and Chun Lei and Li-bin Yang and Yong Zhao and Zhi-ying Weng and Sheng-hong Li and Sheng-xiong Huang and Wei-lie Xiao and HAN, {Simon Quan-Bin} and Han-dong Sun",

year = "2007",

month = dec,

day = "24",

doi = "10.1016/j.tetlet.2007.10.133",

language = "English",

volume = "48",

pages = "9100--9103",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "52",

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TY - JOUR

T1 - Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

AU - Li, Li-mei

AU - Li, Guo-You

AU - Ding, Li-sheng

AU - Lei, Chun

AU - Yang, Li-bin

AU - Zhao, Yong

AU - Weng, Zhi-ying

AU - Li, Sheng-hong

AU - Huang, Sheng-xiong

AU - Xiao, Wei-lie

AU - HAN, Simon Quan-Bin

AU - Sun, Han-dong

PY - 2007/12/24

Y1 - 2007/12/24

N2 - Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.

AB - Three new 6,7-seco-ent-kauranoids (1–3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1–3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound 1 displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 μM, respectively, equal to the positive control. Plausible pathways for the biosynthesis of 1 and 2 from one related diterpenoid were also postulated.

U2 - 10.1016/j.tetlet.2007.10.133

DO - 10.1016/j.tetlet.2007.10.133

M3 - Journal article

SN - 0040-4039

VL - 48

SP - 9100

EP - 9103

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 52

ER -

Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Abstract

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