Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry

Yan Zhou; Sheng-Xiong Huang; Jing-Zheng Song; Chun-Feng Qiao; Song Lin Li; Quan-Bin Han; Hong-Xi Xu

doi:10.1016/j.jasms.2009.06.008

Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry

Yan Zhou, Sheng-Xiong Huang, Jing-Zheng Song, Chun-Feng Qiao, Song Lin Li, Quan-Bin Han, Hong-Xi Xu

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A strategy was newly developed to rapidly screen polycyclic polyprenylated acyl-phloroglucinols (PPAPs) from the plant matrices of nine Garcinia species using ultra-performance liquid chromatography (UPLC) coupled with comprehensive mass spectrometric approaches including precursor ion discovery (PID) and tandem mass (MS/MS) scans. The PPAPs share the same diagnostic product ion at m/z 177. 02 in positive MS/MS scan, which may be increased as the base peak by ramping the cone voltage from 45 to 100 V. With this ramping cone voltage PID scan, it is feasible to selectively screen the PPAPs from 29 samples of nine Garcinia species. This approach has proven to be a powerful, highly selective, and sensitive tool for rapid screening and detection of nontargeted components in natural products before the purification and structural elucidation process.

Original language	English
Pages (from-to)	1846–1850
Journal	Journal of the American Society for Mass Spectrometry
Volume	20
Issue number	10
DOIs	https://doi.org/10.1016/j.jasms.2009.06.008
Publication status	Published - 1 Oct 2009

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Zhou, Y., Huang, S.-X., Song, J.-Z., Qiao, C.-F., Li, S. L., Han, Q.-B., & Xu, H.-X. (2009). Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 20(10), 1846–1850. https://doi.org/10.1016/j.jasms.2009.06.008

Zhou, Yan ; Huang, Sheng-Xiong ; Song, Jing-Zheng et al. / Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry. In: Journal of the American Society for Mass Spectrometry. 2009 ; Vol. 20, No. 10. pp. 1846–1850.

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title = "Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry",

abstract = "A strategy was newly developed to rapidly screen polycyclic polyprenylated acyl-phloroglucinols (PPAPs) from the plant matrices of nine Garcinia species using ultra-performance liquid chromatography (UPLC) coupled with comprehensive mass spectrometric approaches including precursor ion discovery (PID) and tandem mass (MS/MS) scans. The PPAPs share the same diagnostic product ion at m/z 177. 02 in positive MS/MS scan, which may be increased as the base peak by ramping the cone voltage from 45 to 100 V. With this ramping cone voltage PID scan, it is feasible to selectively screen the PPAPs from 29 samples of nine Garcinia species. This approach has proven to be a powerful, highly selective, and sensitive tool for rapid screening and detection of nontargeted components in natural products before the purification and structural elucidation process.",

author = "Yan Zhou and Sheng-Xiong Huang and Jing-Zheng Song and Chun-Feng Qiao and Li, {Song Lin} and Quan-Bin Han and Hong-Xi Xu",

note = "The authors acknowledge support for this research by the Hong Kong Jockey Club Charities Trust Fund. The authors are grateful to Dr. Stephanie Lee of Waters Corporation. ",

year = "2009",

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doi = "10.1016/j.jasms.2009.06.008",

language = "English",

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Zhou, Y, Huang, S-X, Song, J-Z, Qiao, C-F, Li, SL, Han, Q-B & Xu, H-X 2009, 'Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 20, no. 10, pp. 1846–1850. https://doi.org/10.1016/j.jasms.2009.06.008

Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry. / Zhou, Yan; Huang, Sheng-Xiong; Song, Jing-Zheng et al.
In: Journal of the American Society for Mass Spectrometry, Vol. 20, No. 10, 01.10.2009, p. 1846–1850.

Research output: Contribution to journal › Journal article › peer-review

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AU - Huang, Sheng-Xiong

AU - Song, Jing-Zheng

AU - Qiao, Chun-Feng

AU - Li, Song Lin

AU - Han, Quan-Bin

AU - Xu, Hong-Xi

N1 - The authors acknowledge support for this research by the Hong Kong Jockey Club Charities Trust Fund. The authors are grateful to Dr. Stephanie Lee of Waters Corporation.

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AB - A strategy was newly developed to rapidly screen polycyclic polyprenylated acyl-phloroglucinols (PPAPs) from the plant matrices of nine Garcinia species using ultra-performance liquid chromatography (UPLC) coupled with comprehensive mass spectrometric approaches including precursor ion discovery (PID) and tandem mass (MS/MS) scans. The PPAPs share the same diagnostic product ion at m/z 177. 02 in positive MS/MS scan, which may be increased as the base peak by ramping the cone voltage from 45 to 100 V. With this ramping cone voltage PID scan, it is feasible to selectively screen the PPAPs from 29 samples of nine Garcinia species. This approach has proven to be a powerful, highly selective, and sensitive tool for rapid screening and detection of nontargeted components in natural products before the purification and structural elucidation process.

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Zhou Y, Huang SX, Song JZ, Qiao CF, Li SL, Han QB et al. Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 2009 Oct 1;20(10):1846–1850. doi: 10.1016/j.jasms.2009.06.008

Screening of Polycyclic Polyprenylated Acylphloroglucinols from Garcinia Species Using Precursor Ion Discovery (PID) Scan and Ultra Performance Liquid Chromatography Electrospray Ionization Q-TOF Tandem Mass Spectrometry

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