TY - JOUR
T1 - Scorpio and Scolopendra attenuate inflammation and articular damage in rats with collagen-induced arthritis
AU - Liu, Duan Yong
AU - Zhao, Hai Mei
AU - Cheng, Shao Min
AU - Rao, Yi
AU - Huang, Xiao Ying
AU - Zuo, Zhi Qin
AU - Lei, Meng
AU - Guan, Yong Mei
AU - Liu, Hong Ning
AU - LYU, Aiping
N1 - Funding Information:
This work is supported in part by the Project of National Natural Science Foundation of China , No. 30860377 , and by Natural Science Foundation of Jiangxi Province , No. 2009GZY0118 , and Science and Technology Project of Bureau of Health of Jiangxi Province No. 20092052 .
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Ethnopharmacological relevance: Scorpio and Scolopendra (SS) are two traditional Chinese medicines, which are generally used to treat rheumatoid arthritis (RA) in China. However, the mechanism is so far unclear. The purpose of this study was to explore the effects and mechanisms of SS in attenuating inflammation and joint injury in collagen-induced arthritis in rats. Materials and methods: RA was induced in Wistar rats by injection of collagen, meanwhile, the rats were administrated daily either SS (0.4 g/kg, 0.2 g/kg, and 0.1 g/kg) or vehicle (physiological saline) for 42 days. The therapeutic effect of SS on RA was evaluated by pathological methods. T lymphocyte subsets and anti-collagen type II (CII) antibody were tested in peripheral blood. Tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-4 (IL-4) and interleukin-10 (IL-10) were assessed in tissue homogenate of fresh joints. Results: The inflammation and articular damage in SS powder-treated rats were attenuated significantly. In addition, SS powder was revealed to modulate the equilibrium of T lymphocyte subsets, down-regulate TNF-α and IL-1β, up-regulate IL-4 and IL-10, and significantly suppress the level of anti-CII antibody. Conclusions: Scorpio and Scolopendra, when used as a combination, reveal desirable effect for treatment of rheumatoid arthritis, and this beneficial effect may be accomplished through normalization of T lymphocyte subsets and the balance of Th1/Th2 cytokines.
AB - Ethnopharmacological relevance: Scorpio and Scolopendra (SS) are two traditional Chinese medicines, which are generally used to treat rheumatoid arthritis (RA) in China. However, the mechanism is so far unclear. The purpose of this study was to explore the effects and mechanisms of SS in attenuating inflammation and joint injury in collagen-induced arthritis in rats. Materials and methods: RA was induced in Wistar rats by injection of collagen, meanwhile, the rats were administrated daily either SS (0.4 g/kg, 0.2 g/kg, and 0.1 g/kg) or vehicle (physiological saline) for 42 days. The therapeutic effect of SS on RA was evaluated by pathological methods. T lymphocyte subsets and anti-collagen type II (CII) antibody were tested in peripheral blood. Tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-4 (IL-4) and interleukin-10 (IL-10) were assessed in tissue homogenate of fresh joints. Results: The inflammation and articular damage in SS powder-treated rats were attenuated significantly. In addition, SS powder was revealed to modulate the equilibrium of T lymphocyte subsets, down-regulate TNF-α and IL-1β, up-regulate IL-4 and IL-10, and significantly suppress the level of anti-CII antibody. Conclusions: Scorpio and Scolopendra, when used as a combination, reveal desirable effect for treatment of rheumatoid arthritis, and this beneficial effect may be accomplished through normalization of T lymphocyte subsets and the balance of Th1/Th2 cytokines.
KW - Collagen-induced arthritis
KW - Scolopendra
KW - Scorpio
KW - Therapeutic effect
UR - http://www.scopus.com/inward/record.url?scp=84861196651&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2011.08.056
DO - 10.1016/j.jep.2011.08.056
M3 - Journal article
C2 - 21911049
AN - SCOPUS:84861196651
SN - 0378-8741
VL - 141
SP - 603
EP - 607
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -