Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice

Si Yuan Pan*, Xue Lan Song, Zhao Heng Lin, Qing Yu, Yi Zhang, Hai Chuan Tai, Gan Luo, Xiao Yan Wang, Pei Li Zhu, Nan Sun, Zhu Sheng Chu, Zhi Ling Yu, Yi Zhang*, Kam Ming Ko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective

To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus (FSS) and Schisandra chinensis Fructus (FSC) oils in mice. 

Methods

Mice were orally administered a single dose of Schisandrae Fructus oils. Serum and hepatic triglyceride (TG), triglyceride transfer protein (TTP), apolipoprotein B48 (Apo B48), very-low-density lipoprotein (VLDL), hepatocyte growth factor (HGF), alanine aminotransfease (ALT) and liver index were measured at 6-120 h post-dosing. 

Results

FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels, with maximum increases in the liver (by 297% and 340%) at 12 h post-dosing and serum (244% and 439%) at 24-h post-dosing, respectively. Schisandrae Fructus oil treatments also elevated the levels of serum TTP by 51% and 63%, Apo B48 by 152% and 425%, and VLDL by 67% and 38% in mice, respectively. FSS and FSC oil treatments also increased liver mass by 53% and 55% and HGF by 106% and 174%, but lowered serum ALT activity by 38% and 22%, respectively. Fenofibrate pre/ co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41% and 49% at 48 h post-dosing, respectively, but increased hepatic TG contents (by 38% and 33%, respectively) at 12 h post-dosing. 

Conclusions

Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil (mainly increasing endogenous TG) and FSC oil (mainly elevating exogenous TG).

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalAsian Pacific Journal of Tropical Biomedicine
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2022

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

User-Defined Keywords

  • Alanine aminotransferase
  • Hepatomegaly
  • Hypertriglyceridemia
  • Mouse model
  • Schisandrae Fructus oils
  • Triglyceride

Fingerprint

Dive into the research topics of 'Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice'. Together they form a unique fingerprint.

Cite this