Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

Rui Chen; Jinfeng Zhang; Jipsa Chelora; Yuan Xiong; Stephen V. Kershaw; King Fai Li; Pik Kwan Lo; Kok Wai Cheah; Andrey L. Rogach; Juan Antonio Zapien; Chun Sing Lee

doi:10.1021/acsami.6b12469

Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

Rui Chen
, Jinfeng Zhang
, Jipsa Chelora
, Yuan Xiong
, Stephen V. Kershaw
, King Fai Li
, Pik Kwan Lo
, Kok Wai Cheah
, Andrey L. Rogach
, Juan Antonio Zapien
, Chun Sing Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

169 Citations (Scopus)

Abstract

Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)₃²⁺) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)₃²⁺ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)₃²⁺-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)₃²⁺-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)₃²⁺-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

Original language	English
Pages (from-to)	5699-5708
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/acsami.6b12469
Publication status	Published - 22 Feb 2017

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SDG 3 Good Health and Well-being

User-Defined Keywords

metal-organic frameworks
nanoscale metal-organic frameworks
photodynamic therapy
theranostics
two-photon excited fluorescence

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10.1021/acsami.6b12469

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Chen, R., Zhang, J., Chelora, J., Xiong, Y., Kershaw, S. V., Li, K. F., Lo, P. K., Cheah, K. W., Rogach, A. L., Zapien, J. A., & Lee, C. S. (2017). Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Applied Materials and Interfaces, 9(7), 5699-5708. https://doi.org/10.1021/acsami.6b12469

@article{8c03ebac51ad4efca5fbc73689d93439,

title = "Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy",

abstract = "Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.",

keywords = "metal-organic frameworks, nanoscale metal-organic frameworks, photodynamic therapy, theranostics, two-photon excited fluorescence",

author = "Rui Chen and Jinfeng Zhang and Jipsa Chelora and Yuan Xiong and Kershaw, \{Stephen V.\} and Li, \{King Fai\} and Lo, \{Pik Kwan\} and Cheah, \{Kok Wai\} and Rogach, \{Andrey L.\} and Zapien, \{Juan Antonio\} and Lee, \{Chun Sing\}",

note = "Funding information: This project was financially supported by Guangdong Innovative and Entrepreneurial Research Team Program (Nos. 2013C090 and KYPT20141013150545116). Publisher copyright: {\textcopyright} 2017 American Chemical Society",

year = "2017",

month = feb,

day = "22",

doi = "10.1021/acsami.6b12469",

language = "English",

volume = "9",

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journal = "ACS Applied Materials and Interfaces",

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publisher = "American Chemical Society",

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Chen, R, Zhang, J, Chelora, J, Xiong, Y, Kershaw, SV, Li, KF, Lo, PK, Cheah, KW, Rogach, AL, Zapien, JA & Lee, CS 2017, 'Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy', ACS Applied Materials and Interfaces, vol. 9, no. 7, pp. 5699-5708. https://doi.org/10.1021/acsami.6b12469

TY - JOUR

T1 - Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

AU - Chen, Rui

AU - Zhang, Jinfeng

AU - Chelora, Jipsa

AU - Xiong, Yuan

AU - Kershaw, Stephen V.

AU - Li, King Fai

AU - Lo, Pik Kwan

AU - Cheah, Kok Wai

AU - Rogach, Andrey L.

AU - Zapien, Juan Antonio

AU - Lee, Chun Sing

N1 - Funding information: This project was financially supported by Guangdong Innovative and Entrepreneurial Research Team Program (Nos. 2013C090 and KYPT20141013150545116). Publisher copyright: © 2017 American Chemical Society

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

AB - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

KW - metal-organic frameworks

KW - nanoscale metal-organic frameworks

KW - photodynamic therapy

KW - theranostics

KW - two-photon excited fluorescence

UR - https://www.scopus.com/pages/publications/85013395217

U2 - 10.1021/acsami.6b12469

DO - 10.1021/acsami.6b12469

M3 - Journal article

C2 - 28121418

AN - SCOPUS:85013395217

SN - 1944-8244

VL - 9

SP - 5699

EP - 5708

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 7

ER -

Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

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