Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

Rui Chen; Jinfeng Zhang; Jipsa Chelora; Yuan Xiong; Stephen V. Kershaw; King Fai Li; Pik Kwan Lo; Kok Wai Cheah; Andrey L. Rogach; Juan Antonio Zapien; Chun Sing Lee

doi:10.1021/acsami.6b12469

Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

Rui Chen, Jinfeng Zhang, Jipsa Chelora, Yuan Xiong, Stephen V. Kershaw, King Fai Li, Pik Kwan Lo, Kok Wai Cheah, Andrey L. Rogach, Juan Antonio Zapien, Chun Sing Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

150 Citations (Scopus)

Abstract

Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)₃²⁺) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)₃²⁺ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)₃²⁺-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)₃²⁺-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)₃²⁺-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

Original language	English
Pages (from-to)	5699-5708
Number of pages	10
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/acsami.6b12469
Publication status	Published - 22 Feb 2017

Scopus Subject Areas

General Materials Science

User-Defined Keywords

metal-organic frameworks
nanoscale metal-organic frameworks
photodynamic therapy
theranostics
two-photon excited fluorescence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.6b12469

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Chen, R., Zhang, J., Chelora, J., Xiong, Y., Kershaw, S. V., Li, K. F., Lo, P. K., Cheah, K. W., Rogach, A. L., Zapien, J. A., & Lee, C. S. (2017). Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy. ACS Applied Materials and Interfaces, 9(7), 5699-5708. https://doi.org/10.1021/acsami.6b12469

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title = "Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy",

abstract = "Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.",

keywords = "metal-organic frameworks, nanoscale metal-organic frameworks, photodynamic therapy, theranostics, two-photon excited fluorescence",

author = "Rui Chen and Jinfeng Zhang and Jipsa Chelora and Yuan Xiong and Kershaw, {Stephen V.} and Li, {King Fai} and Lo, {Pik Kwan} and Cheah, {Kok Wai} and Rogach, {Andrey L.} and Zapien, {Juan Antonio} and Lee, {Chun Sing}",

note = "Funding information: This project was financially supported by Guangdong Innovative and Entrepreneurial Research Team Program (Nos. 2013C090 and KYPT20141013150545116). Publisher copyright: {\textcopyright} 2017 American Chemical Society",

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doi = "10.1021/acsami.6b12469",

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journal = "ACS Applied Materials and Interfaces",

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Chen, R, Zhang, J, Chelora, J, Xiong, Y, Kershaw, SV, Li, KF, Lo, PK, Cheah, KW, Rogach, AL, Zapien, JA & Lee, CS 2017, 'Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy', ACS Applied Materials and Interfaces, vol. 9, no. 7, pp. 5699-5708. https://doi.org/10.1021/acsami.6b12469

TY - JOUR

T1 - Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

AU - Chen, Rui

AU - Zhang, Jinfeng

AU - Chelora, Jipsa

AU - Xiong, Yuan

AU - Kershaw, Stephen V.

AU - Li, King Fai

AU - Lo, Pik Kwan

AU - Cheah, Kok Wai

AU - Rogach, Andrey L.

AU - Zapien, Juan Antonio

AU - Lee, Chun Sing

N1 - Funding information: This project was financially supported by Guangdong Innovative and Entrepreneurial Research Team Program (Nos. 2013C090 and KYPT20141013150545116). Publisher copyright: © 2017 American Chemical Society

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

AB - Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

KW - metal-organic frameworks

KW - nanoscale metal-organic frameworks

KW - photodynamic therapy

KW - theranostics

KW - two-photon excited fluorescence

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U2 - 10.1021/acsami.6b12469

DO - 10.1021/acsami.6b12469

M3 - Journal article

C2 - 28121418

AN - SCOPUS:85013395217

SN - 1944-8244

VL - 9

SP - 5699

EP - 5708

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 7

ER -

Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

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