Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy

Rui Chen, Jinfeng Zhang, Jipsa Chelora, Yuan Xiong, Stephen V. Kershaw, King Fai Li, Pik Kwan Lo, Kok Wai CHEAH, Andrey L. Rogach, Juan Antonio Zapien, Chun Sing Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

Original languageEnglish
Pages (from-to)5699-5708
Number of pages10
JournalACS applied materials & interfaces
Volume9
Issue number7
DOIs
Publication statusPublished - 22 Feb 2017

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • metal-organic frameworks
  • nanoscale metal-organic frameworks
  • photodynamic therapy
  • theranostics
  • two-photon excited fluorescence

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