Rubescensins S and T: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis

Quan Bin Han; Rong Tao Li; Ji Xia Zhang; Han Dong Sun

doi:10.1002/hlca.200490102

Rubescensins S and T: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis

Quan Bin Han, Rong Tao Li, Ji Xia Zhang, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

34 Citations (Scopus)

Abstract

Two new diterpenoids, rubescensin S (=(1α,6β,14β)-7α, 20-epoxy-1,7,14-trihydroxy-16-oxo-15,16-seco-ent-kauran-6,15-olide; 1) and rubescensin T (=(1α,6β,11β,20S)-7α,20-epoxy-1,6,7- trihydroxy-20-methoxy-8,15-seco-ent-kaur-16-en-11,15-olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16-seco-ent-kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.

Original language	English
Pages (from-to)	1119-1124
Number of pages	6
Journal	Helvetica Chimica Acta
Volume	87
Issue number	5
DOIs	https://doi.org/10.1002/hlca.200490102
Publication status	Published - May 2004

Scopus Subject Areas

Catalysis
Biochemistry
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Rubescensins S and T: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis",

abstract = "Two new diterpenoids, rubescensin S (=(1α,6β,14β)-7α, 20-epoxy-1,7,14-trihydroxy-16-oxo-15,16-seco-ent-kauran-6,15-olide; 1) and rubescensin T (=(1α,6β,11β,20S)-7α,20-epoxy-1,6,7- trihydroxy-20-methoxy-8,15-seco-ent-kaur-16-en-11,15-olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16-seco-ent-kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.",

author = "Han, {Quan Bin} and Li, {Rong Tao} and Zhang, {Ji Xia} and Sun, {Han Dong}",

year = "2004",

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language = "English",

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T1 - Rubescensins S and T: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis

AU - Han, Quan Bin

AU - Li, Rong Tao

AU - Zhang, Ji Xia

AU - Sun, Han Dong

PY - 2004/5

Y1 - 2004/5

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AB - Two new diterpenoids, rubescensin S (=(1α,6β,14β)-7α, 20-epoxy-1,7,14-trihydroxy-16-oxo-15,16-seco-ent-kauran-6,15-olide; 1) and rubescensin T (=(1α,6β,11β,20S)-7α,20-epoxy-1,6,7- trihydroxy-20-methoxy-8,15-seco-ent-kaur-16-en-11,15-olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16-seco-ent-kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.

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DO - 10.1002/hlca.200490102

M3 - Journal article

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JF - Helvetica Chimica Acta

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Rubescensins S and T: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis

Abstract

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