Rubesanolides F and G: Two Novel Lactone-Type Norditerpenoids from Isodon rubescens

Kang He, Juan Zou, Yu-Xue Wang, Chen Liang Zhao, Jiang Hai Ye, Jing-Jie Zhang, Lu-Tai Pan*, Hong Jie Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

5 Citations (Scopus)


A phytochemical investigation of the leaves of the medicinal plant Isodon rubescens led to the isolation of the two new degraded abietane lactone diterpenoids rubesanolides F (1) and G (2). Their structures were elucidated based on the analyses of the HRESIMS and 1D/2D NMR spectral data, and their absolute configurations were determined by ECD spectrum calculations and X-ray single crystal diffraction methods. Compounds 1 and 2, with a unique γ-lactone subgroup between C-8 and C-20, were found to form a carbonyl carbon at C-13 by removal of the isopropyl group in an abietane diterpene skeleton. Rubesanolide G (2) is a rare case of abietane that possesses a cis-fused configuration between rings B and C. The two isolates were evaluated for their biological activities against two cancer cell lines (A549 and HL60), three fungal strains (Candida alba, Aspergillus niger and Rhizopus nigricans) and three bacterial strains (Escherichia coli, Staphylococcus aureus and Bacillus subtilis).
Original languageEnglish
Article number3865
Number of pages9
Issue number13
Publication statusPublished - 24 Jun 2021

User-Defined Keywords

  • Isodon rubescens
  • norditerpenoids
  • ECD calculation
  • single-crystal X-ray diffraction
  • biological activities


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