Rubesanolides C-E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

Juan Zou, Lutai Pan*, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A. Banas, Hongjie ZHANG, Handong Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

Original languageEnglish
Pages (from-to)5039-5044
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number26
DOIs
Publication statusPublished - 14 Jul 2012

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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