Rubesanolides C-E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

Juan Zou; Lutai Pan; Qiji Li; Jianxin Pu; Ping Yao; Min Zhu; Jeffrey A. Banas; Hongjie Zhang; Handong Sun

doi:10.1039/c2ob25192b

Rubesanolides C-E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

Juan Zou, Lutai Pan^*, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A. Banas, Hongjie Zhang, Handong Sun

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

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Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

Original language	English
Pages (from-to)	5039-5044
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	26
DOIs	https://doi.org/10.1039/c2ob25192b
Publication status	Published - 14 Jul 2012

Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Rubesanolides C-E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity",

abstract = "Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.",

author = "Juan Zou and Lutai Pan and Qiji Li and Jianxin Pu and Ping Yao and Min Zhu and Banas, {Jeffrey A.} and Hongjie Zhang and Handong Sun",

note = "This research is funded in part by The Science and Technology Department of Guiyang [No. (2008) 36].",

year = "2012",

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day = "14",

doi = "10.1039/c2ob25192b",

language = "English",

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TY - JOUR

T1 - Rubesanolides C-E

T2 - Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

AU - Zou, Juan

AU - Pan, Lutai

AU - Li, Qiji

AU - Pu, Jianxin

AU - Yao, Ping

AU - Zhu, Min

AU - Banas, Jeffrey A.

AU - Zhang, Hongjie

AU - Sun, Handong

N1 - This research is funded in part by The Science and Technology Department of Guiyang [No. (2008) 36].

PY - 2012/7/14

Y1 - 2012/7/14

N2 - Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

AB - Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

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U2 - 10.1039/c2ob25192b

DO - 10.1039/c2ob25192b

M3 - Journal article

C2 - 22565549

AN - SCOPUS:84862573735

SN - 1477-0520

VL - 10

SP - 5039

EP - 5044

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 26

ER -

Rubesanolides C-E: Abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

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