From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.
|Number of pages||4|
|Early online date||18 Feb 2011|
|Publication status||Published - 18 Mar 2011|
Scopus Subject Areas
- Physical and Theoretical Chemistry
- Organic Chemistry