Rubesanolides A and B: Diterpenoids from Isodon rubescens

Juan Zou, Lutai Pan*, Qiji Li, Junhua Zhao, Jianxin Pu, Ping Yao, Ningbo Gong, Yang Lu, Tamara P. Kondratyuk, John M. Pezzuto, Harry H.S. Fong, Hongjie Zhang*, Handong Sun

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

35 Citations (Scopus)

Abstract

From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.

Original languageEnglish
Pages (from-to)1406-1409
Number of pages4
JournalOrganic Letters
Volume13
Issue number6
Early online date18 Feb 2011
DOIs
Publication statusPublished - 18 Mar 2011

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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