Rubesanolides A and B: Diterpenoids from Isodon rubescens

Juan Zou; Lutai Pan; Qiji Li; Junhua Zhao; Jianxin Pu; Ping Yao; Ningbo Gong; Yang Lu; Tamara P. Kondratyuk; John M. Pezzuto; Harry H.S. Fong; Hongjie Zhang; Handong Sun

doi:10.1021/ol200086k

Rubesanolides A and B: Diterpenoids from Isodon rubescens

Juan Zou, Lutai Pan^*, Qiji Li, Junhua Zhao, Jianxin Pu, Ping Yao, Ningbo Gong, Yang Lu, Tamara P. Kondratyuk, John M. Pezzuto, Harry H.S. Fong, Hongjie Zhang^*, Handong Sun

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.

Original language	English
Pages (from-to)	1406-1409
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	6
Early online date	18 Feb 2011
DOIs	https://doi.org/10.1021/ol200086k
Publication status	Published - 18 Mar 2011

Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol200086k

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title = "Rubesanolides A and B: Diterpenoids from Isodon rubescens",

abstract = "From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.",

author = "Juan Zou and Lutai Pan and Qiji Li and Junhua Zhao and Jianxin Pu and Ping Yao and Ningbo Gong and Yang Lu and Kondratyuk, {Tamara P.} and Pezzuto, {John M.} and Fong, {Harry H.S.} and Hongjie Zhang and Handong Sun",

note = "This research is funded by The Science and Technology Department of Guiyang [No. (2008) 36], and a program project P01 CA48112 awarded by the National Cancer Institute USA, a grant (2005DFA30670). ",

year = "2011",

month = mar,

day = "18",

doi = "10.1021/ol200086k",

language = "English",

volume = "13",

pages = "1406--1409",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Rubesanolides A and B

T2 - Diterpenoids from Isodon rubescens

AU - Zou, Juan

AU - Pan, Lutai

AU - Li, Qiji

AU - Zhao, Junhua

AU - Pu, Jianxin

AU - Yao, Ping

AU - Gong, Ningbo

AU - Lu, Yang

AU - Kondratyuk, Tamara P.

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

AU - Zhang, Hongjie

AU - Sun, Handong

N1 - This research is funded by The Science and Technology Department of Guiyang [No. (2008) 36], and a program project P01 CA48112 awarded by the National Cancer Institute USA, a grant (2005DFA30670).

PY - 2011/3/18

Y1 - 2011/3/18

N2 - From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.

AB - From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.

UR - http://www.scopus.com/inward/record.url?scp=79952576817&partnerID=8YFLogxK

U2 - 10.1021/ol200086k

DO - 10.1021/ol200086k

M3 - Journal article

C2 - 21332131

AN - SCOPUS:79952576817

SN - 1523-7060

VL - 13

SP - 1406

EP - 1409

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Rubesanolides A and B: Diterpenoids from Isodon rubescens

Abstract

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