Rourinoside and rouremin, antimalarial constituents from Rourea minor

Zhen Dan He, Cui Ying Ma, Ghee Teng Tan, Kongmany Sydara, Pamela Tamez, Bounhoong Southavong, Somsanith Bouamanivong, D. Doel Soejarto, John M. Pezzuto, Harry H.S. Fong*, Hongjie ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the antimalarial active CHCl3 extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-β-d-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2′-hydroxypalmitoyl )-octadecasphinga-4,8-dienine, 9S,12S,13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-β-d-glucopyranoside, and β-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.

Original languageEnglish
Pages (from-to)1378-1384
Number of pages7
JournalPhytochemistry
Volume67
Issue number13
DOIs
Publication statusPublished - Jul 2006

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

User-Defined Keywords

  • 2D NMR
  • Antimalarial activity
  • Connaraceae
  • Rourea minor
  • Rouremin
  • Rourinoside

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