@article{d21c9cb7cc784a8ab331459141079174,
title = "Rourinoside and rouremin, antimalarial constituents from Rourea minor",
abstract = "Bioassay-directed fractionation of the antimalarial active CHCl3 extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-β-d-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2′-hydroxypalmitoyl )-octadecasphinga-4,8-dienine, 9S,12S,13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-β-d-glucopyranoside, and β-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.",
keywords = "2D NMR, Antimalarial activity, Connaraceae, Rourea minor, Rouremin, Rourinoside",
author = "He, {Zhen Dan} and Ma, {Cui Ying} and Tan, {Ghee Teng} and Kongmany Sydara and Pamela Tamez and Bounhoong Southavong and Somsanith Bouamanivong and Soejarto, {D. Doel} and Pezzuto, {John M.} and Fong, {Harry H.S.} and Hongjie ZHANG",
note = "Funding Information: All work involving plant sample collection, taxonomic identification, bioassay-guided chemical isolation, and structure elucidation described in this paper were carried out under a NIH Grant 1 UO1-TW01015-01 administered by the Fogarty International Center through funds from NIH, NSF, and USDA Foreign Agricultural Service, as part of an International Cooperative Biodiversity Groups (ICBG) program. Plant collection permit was issued by the Ministry of Agriculture and Forestry of Laos in 1998. Field interviews in Laos were performed under the University of Illinois Institutional Review Board Protocol No. H-97-1056 dated December 2, 1999. The authors are grateful to Nuclear Magnetic Resonance Laboratory of Research Resources Center of University of Illinois at Chicago for access to the Bruker DRX 500 MHz instrument, to the Center Research Group of the College of Pharmacy, University of Illinois at Chicago for the acquisition of MS data, and to Protein Research Laboratory of Research Resources Center of University of Illinois at Chicago for the acquisition of CD spectral data.",
year = "2006",
month = jul,
doi = "10.1016/j.phytochem.2006.04.012",
language = "English",
volume = "67",
pages = "1378--1384",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Ltd.",
number = "13",
}