Roles of Cytokines in Alzheimer’s Disease

Zilin Chen, Yekkuni L. Balachandran, Wai Po Chong*, Kannie W. Y. Chan*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)

Abstract

The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic system that plays a pivotal role in the pathogenesis and progression of Alzheimer’s disease (AD). Of particular focus are cytokines, a group of immune signaling molecules that facilitate communication among immune cells and contribute to inflammation in AD. Extensive research has shown that the dysregulated secretion of certain cytokines (IL-1β, IL-17, IL-12, IL-23, IL-6, and TNF-α) promotes neuroinflammation and exacerbates neuronal damage in AD. However, anti-inflammatory cytokines (IL-2, IL-3, IL-33, and IL-35) are also secreted during AD onset and progression, thereby preventing neuroinflammation. This review summarizes the involvement of pro- and anti-inflammatory cytokines in AD pathology and discusses their therapeutic potential.
Original languageEnglish
Article number5803
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume25
Issue number11
Early online date26 May 2024
DOIs
Publication statusPublished - 1 Jun 2024

User-Defined Keywords

  • Alzheimer’s disease
  • cytokine
  • neuroimmune system
  • pro- and anti-inflammatory cytokines

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