TY - JOUR
T1 - Roles of Cytokines in Alzheimer’s Disease
AU - Chen, Zilin
AU - Balachandran, Yekkuni L.
AU - Chong, Wai Po
AU - Chan, Kannie W. Y.
N1 - Funding information:
This research was funded by Research Grants Council (11102218, 11200422, RFS2223-1S02, C1134-20G); City University of Hong Kong (7005433, 7005626, 9609307, 9610560 and 9610616); Tung Biomedical Sciences Centre; Hong Kong Centre for Cerebrocardiovascular Health Engineering. WPC is supported by the National Natural Science Foundation of China (32370959), Natural Science Foundation of Guangdong province (2021A1515010569, 2022A1515012450), and Hong Kong Baptist University (11.21.4621.AC.162846.00.00).
Publisher copyright:
© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic system that plays a pivotal role in the pathogenesis and progression of Alzheimer’s disease (AD). Of particular focus are cytokines, a group of immune signaling molecules that facilitate communication among immune cells and contribute to inflammation in AD. Extensive research has shown that the dysregulated secretion of certain cytokines (IL-1β, IL-17, IL-12, IL-23, IL-6, and TNF-α) promotes neuroinflammation and exacerbates neuronal damage in AD. However, anti-inflammatory cytokines (IL-2, IL-3, IL-33, and IL-35) are also secreted during AD onset and progression, thereby preventing neuroinflammation. This review summarizes the involvement of pro- and anti-inflammatory cytokines in AD pathology and discusses their therapeutic potential.
AB - The neuroimmune system is a collection of immune cells, cytokines, and the glymphatic system that plays a pivotal role in the pathogenesis and progression of Alzheimer’s disease (AD). Of particular focus are cytokines, a group of immune signaling molecules that facilitate communication among immune cells and contribute to inflammation in AD. Extensive research has shown that the dysregulated secretion of certain cytokines (IL-1β, IL-17, IL-12, IL-23, IL-6, and TNF-α) promotes neuroinflammation and exacerbates neuronal damage in AD. However, anti-inflammatory cytokines (IL-2, IL-3, IL-33, and IL-35) are also secreted during AD onset and progression, thereby preventing neuroinflammation. This review summarizes the involvement of pro- and anti-inflammatory cytokines in AD pathology and discusses their therapeutic potential.
KW - Alzheimer’s disease
KW - cytokine
KW - neuroimmune system
KW - pro- and anti-inflammatory cytokines
UR - https://www.mdpi.com/1422-0067/25/11
UR - http://www.scopus.com/inward/record.url?scp=85195856607&partnerID=8YFLogxK
U2 - 10.3390/ijms25115803
DO - 10.3390/ijms25115803
M3 - Journal article
SN - 1661-6596
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
M1 - 5803
ER -