Roles and Mechanism of Long Noncoding RNAs in Bone Diseases

Dijie Li; Chaofei Yang; Ye Tian; Zhihao Chen; Airong Qian; Chong Yin

doi:10.1007/978-981-16-2402-5_5

Roles and Mechanism of Long Noncoding RNAs in Bone Diseases

Dijie Li, Chaofei Yang, Ye Tian, Zhihao Chen, Airong Qian, Chong Yin^*

^*Corresponding author for this work

Institute for Advancing Translational Medicine in Bone and Joint Diseases

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Close coordination of transcriptional networks and signaling pathways is necessary for the normal function of bone tissue. In pathological bone and cartilage, a lot of these networks/pathways are dysregulated. Long noncoding RNAs (lncRNAs) belong to a kind of RNAs that lack protein-coding potential. LncRNAs are usually more than 200 nucleotides length and play multifarious roles in a wide range of biological functions. In recent decades, an enormous number of lncRNAs have been identified in multiple bone cells and bone diseases and considered to play critical roles. In this chapter, we summarize the current knowledge concerning lncRNAs in bone biology and disease, from their molecular mechanism, pathological implications, and therapeutic potential.

Original language	English
Title of host publication	Noncoding RNAs and Bone
Editors	Airong Qian, Ye Tian
Place of Publication	Singapore
Publisher	Springer
Pages	95-128
Number of pages	34
ISBN (Electronic)	9789811624025
ISBN (Print)	9789811624018
DOIs	https://doi.org/10.1007/978-981-16-2402-5_5
Publication status	Published - 14 Jun 2021

User-Defined Keywords

Bone
Cartilage
Chondrocyte
Long noncoding RNA (lncRNA)
Osteoarthritis
Osteoblast
Osteoclast
Osteoporosis
Osteosarcoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-16-2402-5_5

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abstract = "Close coordination of transcriptional networks and signaling pathways is necessary for the normal function of bone tissue. In pathological bone and cartilage, a lot of these networks/pathways are dysregulated. Long noncoding RNAs (lncRNAs) belong to a kind of RNAs that lack protein-coding potential. LncRNAs are usually more than 200 nucleotides length and play multifarious roles in a wide range of biological functions. In recent decades, an enormous number of lncRNAs have been identified in multiple bone cells and bone diseases and considered to play critical roles. In this chapter, we summarize the current knowledge concerning lncRNAs in bone biology and disease, from their molecular mechanism, pathological implications, and therapeutic potential.",

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note = "This work was supported by the Natural Science Foundation of China (82072106, 81801871, and 81772017), the China Postdoctoral Science Foundation (2020M683573 and 2018T111099), the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University (CX201821). Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2021.",

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AU - Yin, Chong

N1 - This work was supported by the Natural Science Foundation of China (82072106, 81801871, and 81772017), the China Postdoctoral Science Foundation (2020M683573 and 2018T111099), the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University (CX201821). Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2021.

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KW - Cartilage

KW - Chondrocyte

KW - Long noncoding RNA (lncRNA)

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KW - Osteoblast

KW - Osteoclast

KW - Osteoporosis

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ER -

Roles and Mechanism of Long Noncoding RNAs in Bone Diseases

Abstract

User-Defined Keywords

UN SDGs

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