Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis

H. T. Wan, Dolores D. Mruk, Elizabeth I. Tang, Xiang Xiao, Yan Ho Cheng, Elissa W.P. Wong, Chris K C WONG, C. Yan Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Non-receptor protein tyrosine kinases are cytoplasmic kinases that activate proteins by phosphorylating tyrosine residues, which in turn affect multiple functions in eukaryotic cells. Herein, we focus on the role of non-receptor protein tyrosine kinases, most notably, FAK, c-Yes and c-Src, in the transport of spermatids across the seminiferous epithelium during spermatogenesis. Since spermatids, which are formed from spermatocytes via meiosis, are immotile haploid cells, they must be transported by Sertoli cells across the seminiferous epithelium during the epithelial cycle of spermatogenesis. Without the timely transport of spermatids across the epithelium, the release of sperms at spermiation fails to occur, leading to infertility. Thus, the molecular event pertinent to spermatid transport is crucial to spermatogenesis. We provide a critical discussion based on recent findings in this review. We also provide a hypothetical model on spermatid transport, and the role of non-receptor protein tyrosine kinases in this event. We also highlight areas of research that deserve attention by investigators in the field.

Original languageEnglish
Pages (from-to)65-74
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume30
DOIs
Publication statusPublished - Jun 2014

Scopus Subject Areas

  • Developmental Biology
  • Cell Biology

User-Defined Keywords

  • Blood-testis barrier
  • C-Src
  • C-Yes
  • Cell adhesion
  • FAK
  • Seminiferous epithelial cycle
  • Spermatogenesis
  • Spermiation
  • Spermiogenesis
  • Testis

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