Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Yasir Arfat; Wei Zhong Xiao; Munazza Ahmad; Fan Zhao; Di Jie Li; Yu Long Sun; Lifang Hu; Zhihao Chen; Ge Zhang; Salman Iftikhar; Peng Shang; Tuan Ming Yang; Ai Rong Qian

doi:10.2174/0929867321999141106121227

Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Yasir Arfat, Wei Zhong Xiao, Munazza Ahmad, Fan Zhao, Di Jie Li, Yu Long Sun, Lifang Hu, Zhihao Chen, Ge Zhang, Salman Iftikhar, Peng Shang, Tuan Ming Yang^*, Ai Rong Qian^*

^*Corresponding author for this work

Institute for Advancing Translational Medicine in Bone and Joint Diseases

Research output: Contribution to journal › Journal article › peer-review

44 Citations (Scopus)

Abstract

Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

Original language	English
Pages (from-to)	748-758
Number of pages	11
Journal	Current Medicinal Chemistry
Volume	22
Issue number	6
DOIs	https://doi.org/10.2174/0929867321999141106121227
Publication status	Published - Feb 2015

Scopus Subject Areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

User-Defined Keywords

Bone disorder
MicroRNAs
Osteoblasts differentiation
Signaling pathways

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10.2174/0929867321999141106121227

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title = "Role of microRNAs in Osteoblasts Differentiation and Bone Disorders",

abstract = "Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.",

keywords = "Bone disorder, MicroRNAs, Osteoblasts differentiation, Signaling pathways",

author = "Yasir Arfat and Xiao, {Wei Zhong} and Munazza Ahmad and Fan Zhao and Li, {Di Jie} and Sun, {Yu Long} and Lifang Hu and Zhihao Chen and Ge Zhang and Salman Iftikhar and Peng Shang and Yang, {Tuan Ming} and Qian, {Ai Rong}",

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year = "2015",

month = feb,

doi = "10.2174/0929867321999141106121227",

language = "English",

volume = "22",

pages = "748--758",

journal = "Current Medicinal Chemistry",

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T1 - Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

AU - Arfat, Yasir

AU - Xiao, Wei Zhong

AU - Ahmad, Munazza

AU - Zhao, Fan

AU - Li, Di Jie

AU - Sun, Yu Long

AU - Hu, Lifang

AU - Chen, Zhihao

AU - Zhang, Ge

AU - Iftikhar, Salman

AU - Shang, Peng

AU - Yang, Tuan Ming

AU - Qian, Ai Rong

PY - 2015/2

Y1 - 2015/2

N2 - Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

AB - Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

KW - Bone disorder

KW - MicroRNAs

KW - Osteoblasts differentiation

KW - Signaling pathways

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U2 - 10.2174/0929867321999141106121227

DO - 10.2174/0929867321999141106121227

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AN - SCOPUS:84922984458

SN - 0929-8673

VL - 22

SP - 748

EP - 758

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 6

ER -

Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Abstract

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