Role of microRNAs in osteoblasts differentiation and bone disorders yasir arfat1

Wei Zhong Xiao, Munazza Ahmad, Fan Zhao, Di Jie Li, Yu Long Sun, Lifang Hu, Chen Zhihao, Ge ZHANG, Salman Iftikhar, Peng Shang, Tuan Ming Yang, Ai Rong Qian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Advanced studies of single stranded endogenous ∼22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFα, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

Original languageEnglish
Pages (from-to)748-758
Number of pages11
JournalCurrent Medicinal Chemistry
Volume22
Issue number6
DOIs
Publication statusPublished - 2015

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Bone disorder
  • MicroRNAs
  • Osteoblasts differentiation
  • Signaling pathways

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