Risk assessment of bioaccessible organochlorine pesticides exposure via indoor and outdoor dust

Wei Wang; Min Juan Huang; Fu Yong Wu; Yuan Kang; Hong Sheng Wang; Kwai Chung Cheung; Ming Hung Wong

doi:10.1016/j.atmosenv.2013.04.071

Risk assessment of bioaccessible organochlorine pesticides exposure via indoor and outdoor dust

Wei Wang, Min Juan Huang, Fu Yong Wu, Yuan Kang, Hong Sheng Wang, Kwai Chung Cheung, Ming Hung Wong^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

40 Citations (Scopus)

Abstract

Dust, enriched by dichlorodiphenyltrichloroethanes (DDTs), was defined as a new route of organochlorine pesticides (OCPs) exposure, especially for children. Chemical analyses showed the medians of ∑OCPs were 171 (outdoor) and 520 (indoor) μgkg^-1 in Guangzhou (GZ) while 130 (outdoor) and 115 (indoor) μgkg^-1 in Hong Kong (HK). Significantly higher accumulative effect of OCPs occurred in the size fractions of <63 and 63-100μm than 100-280 and 280-2000μm, therefore 0-100μm dust particles were used for risk evaluation. Different cytotoxic effects on human hepatocellular live carcinoma cell (HepG2) and human skin keratinocyte cell line (KERTr) were found for extracts of indoor dust and outdoor dust from different functional areas. For total exposure (dust and food), OCPs intake via dust was low for adults (accounting for 0.16-3.78% of total exposure), while for children it was high (8.16-24.4% of total exposure). Non-carcinogenic OCPs exposure via dust was safe for adults; however DDT and Dieldrin exposure for children was higher than Reference Dose (RfD). The cancer risk related to indoor dust exposure for GZ and HK was moderate, below 10^-4, while 42% of residences in GZ should be of concern (10^-5). However, when bioaccessible OCPs used, daily intake and health risk were found to be greatly lower than the estimates without considering bioaccessibility.

Original language	English
Pages (from-to)	525-533
Number of pages	9
Journal	Atmospheric Environment
Volume	77
DOIs	https://doi.org/10.1016/j.atmosenv.2013.04.071
Publication status	Published - Oct 2013

Scopus Subject Areas

General Environmental Science
Atmospheric Science

User-Defined Keywords

Bioaccessibility
Daily exposure
In vitro cytotoxicity
Size fraction effect

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atmosenv.2013.04.071

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title = "Risk assessment of bioaccessible organochlorine pesticides exposure via indoor and outdoor dust",

abstract = "Dust, enriched by dichlorodiphenyltrichloroethanes (DDTs), was defined as a new route of organochlorine pesticides (OCPs) exposure, especially for children. Chemical analyses showed the medians of ∑OCPs were 171 (outdoor) and 520 (indoor) μgkg-1 in Guangzhou (GZ) while 130 (outdoor) and 115 (indoor) μgkg-1 in Hong Kong (HK). Significantly higher accumulative effect of OCPs occurred in the size fractions of <63 and 63-100μm than 100-280 and 280-2000μm, therefore 0-100μm dust particles were used for risk evaluation. Different cytotoxic effects on human hepatocellular live carcinoma cell (HepG2) and human skin keratinocyte cell line (KERTr) were found for extracts of indoor dust and outdoor dust from different functional areas. For total exposure (dust and food), OCPs intake via dust was low for adults (accounting for 0.16-3.78% of total exposure), while for children it was high (8.16-24.4% of total exposure). Non-carcinogenic OCPs exposure via dust was safe for adults; however DDT and Dieldrin exposure for children was higher than Reference Dose (RfD). The cancer risk related to indoor dust exposure for GZ and HK was moderate, below 10-4, while 42% of residences in GZ should be of concern (10-5). However, when bioaccessible OCPs used, daily intake and health risk were found to be greatly lower than the estimates without considering bioaccessibility.",

keywords = "Bioaccessibility, Daily exposure, In vitro cytotoxicity, Size fraction effect",

author = "Wei Wang and Huang, {Min Juan} and Wu, {Fu Yong} and Yuan Kang and Wang, {Hong Sheng} and Cheung, {Kwai Chung} and Wong, {Ming Hung}",

note = "Funding Information: Financial support from the Research Grants Council of the University Grants Committee of Hong Kong (HKBU 260209; N_HKBU210/11) is gratefully acknowledged. ",

year = "2013",

month = oct,

doi = "10.1016/j.atmosenv.2013.04.071",

language = "English",

volume = "77",

pages = "525--533",

journal = "Atmospheric Environment",

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T1 - Risk assessment of bioaccessible organochlorine pesticides exposure via indoor and outdoor dust

AU - Wang, Wei

AU - Huang, Min Juan

AU - Wu, Fu Yong

AU - Kang, Yuan

AU - Wang, Hong Sheng

AU - Cheung, Kwai Chung

AU - Wong, Ming Hung

N1 - Funding Information: Financial support from the Research Grants Council of the University Grants Committee of Hong Kong (HKBU 260209; N_HKBU210/11) is gratefully acknowledged.

PY - 2013/10

Y1 - 2013/10

N2 - Dust, enriched by dichlorodiphenyltrichloroethanes (DDTs), was defined as a new route of organochlorine pesticides (OCPs) exposure, especially for children. Chemical analyses showed the medians of ∑OCPs were 171 (outdoor) and 520 (indoor) μgkg-1 in Guangzhou (GZ) while 130 (outdoor) and 115 (indoor) μgkg-1 in Hong Kong (HK). Significantly higher accumulative effect of OCPs occurred in the size fractions of <63 and 63-100μm than 100-280 and 280-2000μm, therefore 0-100μm dust particles were used for risk evaluation. Different cytotoxic effects on human hepatocellular live carcinoma cell (HepG2) and human skin keratinocyte cell line (KERTr) were found for extracts of indoor dust and outdoor dust from different functional areas. For total exposure (dust and food), OCPs intake via dust was low for adults (accounting for 0.16-3.78% of total exposure), while for children it was high (8.16-24.4% of total exposure). Non-carcinogenic OCPs exposure via dust was safe for adults; however DDT and Dieldrin exposure for children was higher than Reference Dose (RfD). The cancer risk related to indoor dust exposure for GZ and HK was moderate, below 10-4, while 42% of residences in GZ should be of concern (10-5). However, when bioaccessible OCPs used, daily intake and health risk were found to be greatly lower than the estimates without considering bioaccessibility.

AB - Dust, enriched by dichlorodiphenyltrichloroethanes (DDTs), was defined as a new route of organochlorine pesticides (OCPs) exposure, especially for children. Chemical analyses showed the medians of ∑OCPs were 171 (outdoor) and 520 (indoor) μgkg-1 in Guangzhou (GZ) while 130 (outdoor) and 115 (indoor) μgkg-1 in Hong Kong (HK). Significantly higher accumulative effect of OCPs occurred in the size fractions of <63 and 63-100μm than 100-280 and 280-2000μm, therefore 0-100μm dust particles were used for risk evaluation. Different cytotoxic effects on human hepatocellular live carcinoma cell (HepG2) and human skin keratinocyte cell line (KERTr) were found for extracts of indoor dust and outdoor dust from different functional areas. For total exposure (dust and food), OCPs intake via dust was low for adults (accounting for 0.16-3.78% of total exposure), while for children it was high (8.16-24.4% of total exposure). Non-carcinogenic OCPs exposure via dust was safe for adults; however DDT and Dieldrin exposure for children was higher than Reference Dose (RfD). The cancer risk related to indoor dust exposure for GZ and HK was moderate, below 10-4, while 42% of residences in GZ should be of concern (10-5). However, when bioaccessible OCPs used, daily intake and health risk were found to be greatly lower than the estimates without considering bioaccessibility.

KW - Bioaccessibility

KW - Daily exposure

KW - In vitro cytotoxicity

KW - Size fraction effect

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U2 - 10.1016/j.atmosenv.2013.04.071

DO - 10.1016/j.atmosenv.2013.04.071

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AN - SCOPUS:84879516904

SN - 1352-2310

VL - 77

SP - 525

EP - 533

JO - Atmospheric Environment

JF - Atmospheric Environment

ER -

Risk assessment of bioaccessible organochlorine pesticides exposure via indoor and outdoor dust

Abstract

Scopus Subject Areas

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UN SDGs

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