Rhodium-Catalyzed Enantioselective Hydroselenation of Heterobicyclic Alkenes

Sifeng Li, Qingjing Yang, Zhaoxiang Bian*, Jun Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

22 Citations (Scopus)


A highly efficient Rh(I)/(S)-xyl-Binap catalytic system is developed for the asymmetric hydroselenation of various nonpolar olefins with diselenides. Under these mild reaction conditions, a wide range of heterobicyclic alkenes give selenol-incorporated adducts in excellent enantioselectivities (up to 97%) along with high yields (up to 96%) by overcoming self-promoted racemic hydroselenation. The strategy is also applied for kinetic resolution of unsymmetric oxabenzonorbornadiene.

Original languageEnglish
Pages (from-to)2781-2785
Number of pages5
JournalOrganic Letters
Issue number7
Early online date20 Mar 2020
Publication statusPublished - 3 Apr 2020

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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