Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Phthaliminoacrylate Esters toward the Synthesis of β-Amino Acids

Takahiro Nishimura, Jun Wang, Makoto Nagaosa, Kazuhiro Okamoto, Ryo Shintani, Fuk-yee Kwong, Wing-yiu Yu, Albert S C Chan, Tamio Hayashi

Research output: Contribution to journalJournal articlepeer-review

70 Citations (Scopus)

Abstract

Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to β-phthaliminoacrylate esters took place efficiently to give high yields of β-aryl-β-amino acid esters with 96−99% enantioselectivity, which was realized by use of a hydroxorhodium/chiral diene complex.
Original languageEnglish
Pages (from-to)464–465
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number2
Early online date22 Dec 2009
DOIs
Publication statusPublished - 20 Jan 2010

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