Reversible brain white matter microstructure changes in heroin addicts: a longitudinal study

Xuyi Wang; Rongjun Yu; Xuhui Zhou; Yanhui Liao; Jinsong Tang; Tieqiao Liu; Baoci Shan; Wei Hao

doi:10.1111/j.1369-1600.2011.00316.x

Reversible brain white matter microstructure changes in heroin addicts: a longitudinal study

Xuyi Wang, Rongjun Yu, Xuhui Zhou, Yanhui Liao, Jinsong Tang, Tieqiao Liu, Baoci Shan, Wei Hao^*

^*Corresponding author for this work

Department of Management, Marketing and Information Systems

Research output: Contribution to journal › Journal article › peer-review

17 Citations (Scopus)

Abstract

Previous neuroimaging studies have documented the structural damage in heroin addicts. However, little research has detailed the white matter microstructural changes in the human brain as a result of chronic heroin use and importantly, whether such changes can be recovered after short-term abstinence. Decreased fractional anisotropy values in frontal cortex were found in heroin users after 3 days of abstinence in comparison with controls. However, no significant difference was found between these heroin addicts and controls after 1-month abstinence. These results might better our understanding of the biological basis of drug addiction and provide insight into addiction treatment.

Original language	English
Pages (from-to)	727-728
Number of pages	2
Journal	Addiction Biology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1369-1600.2011.00316.x
Publication status	Published - Jul 2013

User-Defined Keywords

Cingulate gyrus
diffusion tensor imaging
fractional anisotropy
frontal gyrus
heroin addiction
white matter

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10.1111/j.1369-1600.2011.00316.x

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title = "Reversible brain white matter microstructure changes in heroin addicts: a longitudinal study",

abstract = "Previous neuroimaging studies have documented the structural damage in heroin addicts. However, little research has detailed the white matter microstructural changes in the human brain as a result of chronic heroin use and importantly, whether such changes can be recovered after short-term abstinence. Decreased fractional anisotropy values in frontal cortex were found in heroin users after 3 days of abstinence in comparison with controls. However, no significant difference was found between these heroin addicts and controls after 1-month abstinence. These results might better our understanding of the biological basis of drug addiction and provide insight into addiction treatment.",

keywords = "Cingulate gyrus, diffusion tensor imaging, fractional anisotropy, frontal gyrus, heroin addiction, white matter",

author = "Xuyi Wang and Rongjun Yu and Xuhui Zhou and Yanhui Liao and Jinsong Tang and Tieqiao Liu and Baoci Shan and Wei Hao",

note = "Publisher copyright: {\textcopyright} 2011 The Authors, Addiction Biology {\textcopyright} 2011 Society for the Study of Addiction",

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AU - Wang, Xuyi

AU - Yu, Rongjun

AU - Zhou, Xuhui

AU - Liao, Yanhui

AU - Tang, Jinsong

AU - Liu, Tieqiao

AU - Shan, Baoci

AU - Hao, Wei

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N2 - Previous neuroimaging studies have documented the structural damage in heroin addicts. However, little research has detailed the white matter microstructural changes in the human brain as a result of chronic heroin use and importantly, whether such changes can be recovered after short-term abstinence. Decreased fractional anisotropy values in frontal cortex were found in heroin users after 3 days of abstinence in comparison with controls. However, no significant difference was found between these heroin addicts and controls after 1-month abstinence. These results might better our understanding of the biological basis of drug addiction and provide insight into addiction treatment.

AB - Previous neuroimaging studies have documented the structural damage in heroin addicts. However, little research has detailed the white matter microstructural changes in the human brain as a result of chronic heroin use and importantly, whether such changes can be recovered after short-term abstinence. Decreased fractional anisotropy values in frontal cortex were found in heroin users after 3 days of abstinence in comparison with controls. However, no significant difference was found between these heroin addicts and controls after 1-month abstinence. These results might better our understanding of the biological basis of drug addiction and provide insight into addiction treatment.

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KW - diffusion tensor imaging

KW - fractional anisotropy

KW - frontal gyrus

KW - heroin addiction

KW - white matter

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DO - 10.1111/j.1369-1600.2011.00316.x

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EP - 728

JO - Addiction Biology

JF - Addiction Biology

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ER -

Reversible brain white matter microstructure changes in heroin addicts: a longitudinal study

Abstract

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