Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

David W F FONG; C. Wang; G. Y. Zhu; C. H. Leung; M. S. Yang; H. Y. Cheung

doi:10.1016/j.phymed.2006.03.004

Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

David W F FONG^*, C. Wang, G. Y. Zhu, C. H. Leung, M. S. Yang, H. Y. Cheung

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

56 Citations (Scopus)

Abstract

Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G₂/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp.

Original language	English
Pages (from-to)	160-165
Number of pages	6
Journal	Phytomedicine
Volume	14
Issue number	2-3
DOIs	https://doi.org/10.1016/j.phymed.2006.03.004
Publication status	Published - 19 Feb 2007

Scopus Subject Areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

User-Defined Keywords

HepG2-DR cells
K562-DR cells
Multidrug resistance
P-glycoprotein
Rhizoma Alismatis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2006.03.004

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title = "Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract",

abstract = "Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp.",

keywords = "HepG2-DR cells, K562-DR cells, Multidrug resistance, P-glycoprotein, Rhizoma Alismatis",

author = "FONG, {David W F} and C. Wang and Zhu, {G. Y.} and Leung, {C. H.} and Yang, {M. S.} and Cheung, {H. Y.}",

note = "Funding Information: This work was supported in full by City University of Hong Kong Strategic Research Grant 7001110.",

year = "2007",

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doi = "10.1016/j.phymed.2006.03.004",

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journal = "Phytomedicine",

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T1 - Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

AU - FONG, David W F

AU - Wang, C.

AU - Zhu, G. Y.

AU - Leung, C. H.

AU - Yang, M. S.

AU - Cheung, H. Y.

N1 - Funding Information: This work was supported in full by City University of Hong Kong Strategic Research Grant 7001110.

PY - 2007/2/19

Y1 - 2007/2/19

N2 - Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp.

AB - Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp.

KW - HepG2-DR cells

KW - K562-DR cells

KW - Multidrug resistance

KW - P-glycoprotein

KW - Rhizoma Alismatis

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M3 - Journal article

C2 - 16713217

AN - SCOPUS:33846397852

SN - 0944-7113

VL - 14

SP - 160

EP - 165

JO - Phytomedicine

JF - Phytomedicine

IS - 2-3

ER -

Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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