TY - JOUR
T1 - Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies
AU - Su, Cheng Fu
AU - Jiang, Li
AU - Zhang, Xiao-Wen
AU - Iyaswamy, Ashok
AU - Li, Min
N1 - Funding Information:
This research work was sponsored by some of our grants from the Health Medical Research Fund, Food and Health Bureau, Hong Kong S.A.R. (HMRF 17182541, HMRF 17182551, and HMRF-17182561). The National Natural Science Foundation of China (81703487, 81773926), the Hong Kong General Research Fund (GRF/HKBU12101417, GRF/HKBU12100618), and research fund from Hong Kong Baptist University (HKBU/RC-IRCs/17-18/03, IRCMS/19-20/H02) and (GDS-84/506/2019).
Publisher Copyright:
© 2021 Su, Jiang, Zhang, Iyaswamy and Li.
PY - 2021/4/22
Y1 - 2021/4/22
N2 - Parkinson’s disease (PD) is a common neurodegenerative disease featured
by progressive degeneration of nigrostriatal dopaminergic neurons (DA)
accompanied with motor function impairment. Accumulating evidence has
demonstrated that natural compounds from herbs have potent anti-PD
efficacy in PD models. Among those compounds, resveratrol, a polyphenol
found in many common plants and fruits, is more effective against PD.
Resveratrol has displayed a potent neuroprotective efficacy in several
PD animal models. However, there is still no systematic analysis of the
quality of methodological design of these studies, nor of their results.
In this review, we retrieved and analyzed 18 studies describing the
therapeutic effect of resveratrol on PD animal models. There are 5 main
kinds of PD rodent models involved in the 18 articles, including
chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and
transgenic PD models. The neuroprotective mechanisms of resveratrol were
mainly concentrated on the antioxidation, anti-inflammation,
ameliorating mitochondrial dysfunction, and motor function. We discussed
the disadvantages of different PD animal models, and we used
meta-analysis approach to evaluate the results of the selected studies
and used SYRCLE’s risk of bias tool to evaluate the methodological
quality. Our analytical approach minimized the bias of different
studies. We have also summarized the pharmacological mechanisms of
resveratrol on PD models as reported by the researchers. The results of
this study support the notion that resveratrol has significant
neuroprotective effects on different PD models quantified using
qualitative and quantitative methods. The collective information in our
review can guide researchers to further plan their future experiments
without any hassle regarding preclinical and clinical studies. In
addition, this collective assessment of animal studies can provide a
qualitative analysis of different PD animal models, either to guide
further testing of these models or to avoid unnecessary duplication in
their future research.
AB - Parkinson’s disease (PD) is a common neurodegenerative disease featured
by progressive degeneration of nigrostriatal dopaminergic neurons (DA)
accompanied with motor function impairment. Accumulating evidence has
demonstrated that natural compounds from herbs have potent anti-PD
efficacy in PD models. Among those compounds, resveratrol, a polyphenol
found in many common plants and fruits, is more effective against PD.
Resveratrol has displayed a potent neuroprotective efficacy in several
PD animal models. However, there is still no systematic analysis of the
quality of methodological design of these studies, nor of their results.
In this review, we retrieved and analyzed 18 studies describing the
therapeutic effect of resveratrol on PD animal models. There are 5 main
kinds of PD rodent models involved in the 18 articles, including
chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and
transgenic PD models. The neuroprotective mechanisms of resveratrol were
mainly concentrated on the antioxidation, anti-inflammation,
ameliorating mitochondrial dysfunction, and motor function. We discussed
the disadvantages of different PD animal models, and we used
meta-analysis approach to evaluate the results of the selected studies
and used SYRCLE’s risk of bias tool to evaluate the methodological
quality. Our analytical approach minimized the bias of different
studies. We have also summarized the pharmacological mechanisms of
resveratrol on PD models as reported by the researchers. The results of
this study support the notion that resveratrol has significant
neuroprotective effects on different PD models quantified using
qualitative and quantitative methods. The collective information in our
review can guide researchers to further plan their future experiments
without any hassle regarding preclinical and clinical studies. In
addition, this collective assessment of animal studies can provide a
qualitative analysis of different PD animal models, either to guide
further testing of these models or to avoid unnecessary duplication in
their future research.
KW - meta-analysis
KW - neuroprotective effects
KW - Parkinson’s disease
KW - PD animal models
KW - resveratrol
UR - http://www.scopus.com/inward/record.url?scp=85105526152&partnerID=8YFLogxK
U2 - 10.3389/fphar.2021.644219
DO - 10.3389/fphar.2021.644219
M3 - Review article
AN - SCOPUS:85105526152
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 644219
ER -