Resting and post-exercise serum biomarkers of cardiac and skeletal muscle damage in adolescent runners

Jinlei Nie*, Tom K K TONG, K. George, Frank H K FU, H. Lin, Q. Shi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

This study examined the response of serum biomarkers of cardiac and skeletal muscle damage at rest and after a routine workout of 21km run in 12 male adolescent (16.2±0.6 years) long-distance runners. Biomarkers of cardiac [troponins (cTnT, cTnI), creatine kinase MB mass (CK-Mbmass)] and skeletal muscle [creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and hydroxybutyrate dehydrogenase (HBD)] damage were assayed at rest, 2, 4 and 24h post-exercise. At rest, cTnT and cTnI were not detectable; however, CK, CK-MBmass, AST, ALT and HBD were above corresponding clinical cut-off values. Post-exercise significant elevations above rest were observed for all biomarkers, except ALT, 2 and 4h following the run, and remained elevated in cTnI, CK, CK-MBmass, LDH and AST 24h post-workout. A significant increase in data points above clinical cut-off values from rest to post-exercise was reported for cTnT, cTnI and CK at 2 and 4h, and in cTnI and CK 24h post-exercise. In conclusion, a 21km run in adolescent runners increased post-exercise biomarkers of cardiac and skeletal muscle damage.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalScandinavian Journal of Medicine and Science in Sports
Volume21
Issue number5
DOIs
Publication statusPublished - Oct 2011

Scopus Subject Areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

User-Defined Keywords

  • Biomarkers
  • Junior athletes
  • Musculature
  • Training
  • Troponins

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