Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1

Shuai Zha; Yan Ho Fung; Ho Fai Chau; Ping'An Ma; Jun Lin; Jing Wang; Lai Sheung Chan; Guang Zhu; Hong Lok Lung; Ka-Leung Wong

doi:10.1039/c8nr05015e

Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1

Shuai Zha
, Yan Ho Fung
, Ho Fai Chau
, Ping'An Ma
, Jun Lin
, Jing Wang
, Lai Sheung Chan
, Guang Zhu
, Hong Lok Lung^*
, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

28 Citations (Scopus)

Abstract

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF₄:Yb³⁺,Er³⁺@NaGdF₄ (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein-EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

Original language	English
Pages (from-to)	15632-15640
Number of pages	9
Journal	Nanoscale
Volume	10
Issue number	33
Early online date	6 Aug 2018
DOIs	https://doi.org/10.1039/c8nr05015e
Publication status	Published - 7 Sept 2018

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10.1039/c8nr05015e

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@article{4a337602acb04e42aef04e87283d51c4,

title = "Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1",

abstract = "Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein-EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.",

author = "Shuai Zha and Fung, \{Yan Ho\} and Chau, \{Ho Fai\} and Ping'An Ma and Jun Lin and Jing Wang and Chan, \{Lai Sheung\} and Guang Zhu and Lung, \{Hong Lok\} and Ka-Leung Wong",

note = "Funding Information: This work was supported by grants from Hong Kong Baptist University (RC-ICRS/16-17/1B-CHE) and Hong Kong Research Grants Council (HKBU 22301615), the National Natural Science Foundation of China (NSFC 21728101) and the CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204).",

year = "2018",

month = sep,

day = "7",

doi = "10.1039/c8nr05015e",

language = "English",

volume = "10",

pages = "15632--15640",

journal = "Nanoscale",

issn = "2040-3364",

publisher = "Royal Society of Chemistry",

number = "33",

}

TY - JOUR

T1 - Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1

AU - Zha, Shuai

AU - Fung, Yan Ho

AU - Chau, Ho Fai

AU - Ma, Ping'An

AU - Lin, Jun

AU - Wang, Jing

AU - Chan, Lai Sheung

AU - Zhu, Guang

AU - Lung, Hong Lok

AU - Wong, Ka-Leung

N1 - Funding Information: This work was supported by grants from Hong Kong Baptist University (RC-ICRS/16-17/1B-CHE) and Hong Kong Research Grants Council (HKBU 22301615), the National Natural Science Foundation of China (NSFC 21728101) and the CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204).

PY - 2018/9/7

Y1 - 2018/9/7

N2 - Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein-EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

AB - Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein-EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

UR - https://www.scopus.com/pages/publications/85052496611

U2 - 10.1039/c8nr05015e

DO - 10.1039/c8nr05015e

M3 - Journal article

C2 - 30090884

AN - SCOPUS:85052496611

SN - 2040-3364

VL - 10

SP - 15632

EP - 15640

JO - Nanoscale

JF - Nanoscale

IS - 33

ER -

Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1

Abstract

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