Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers Via targeting EBNA1

Shuai Zha, Yan Ho Fung, Ho Fai Chau, Ping'An Ma, Jun Lin, Jing Wang, Lai Sheung Chan, Guang Zhu, Hong Lok LUNG*, Ka-Leung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein-EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.

Original languageEnglish
Pages (from-to)15632-15640
Number of pages9
JournalNanoscale
Volume10
Issue number33
DOIs
Publication statusPublished - 1 Aug 2018

Scopus Subject Areas

  • Materials Science(all)

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