Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Shuzhong He; Hongguang Li; Yuk Wang Yip; Chi Tung Yeung; Yuen On Fung; Hoi Kuan Kong; Ho Lun Yeung; Ga Lai Law; Ka-Leung Wong; Chi Sing Lee; Michael Hon Wah Lam; Margaret B. Murphy; Paul Kwan Sing Lam; Wing Tak Wong

doi:10.1021/ol2018246

Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Shuzhong He
, Hongguang Li
, Yuk Wang Yip
, Chi Tung Yeung
, Yuen On Fung
, Hoi Kuan Kong
, Ho Lun Yeung
, Ga Lai Law
, Ka-Leung Wong
, Chi Sing Lee^*
, Michael Hon Wah Lam
, Margaret B. Murphy
, Paul Kwan Sing Lam
, Wing Tak Wong

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

5 Citations (Scopus)

Abstract

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K_B= 6.1×10⁴M^-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

Original language	English
Pages (from-to)	5036-5039
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	19
DOIs	https://doi.org/10.1021/ol2018246
Publication status	Published - 7 Oct 2011

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10.1021/ol2018246

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@article{0689ae08d1284426a79c614a4b269581,

title = "Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin",

abstract = "A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100\% and increases the two-photon absorption crosssection from 9 to 36 GM.",

author = "Shuzhong He and Hongguang Li and Yip, \{Yuk Wang\} and Yeung, \{Chi Tung\} and Fung, \{Yuen On\} and Kong, \{Hoi Kuan\} and Yeung, \{Ho Lun\} and Law, \{Ga Lai\} and Ka-Leung Wong and Lee, \{Chi Sing\} and Lam, \{Michael Hon Wah\} and Murphy, \{Margaret B.\} and Lam, \{Paul Kwan Sing\} and Wong, \{Wing Tak\}",

note = "This work was funded by grants from The Hong Kong Research Grants Council, the Hong Kong Polytechnic University (PolyU 503211P), City University of Hong Kong (CityU3/CRF/08), Peking University Shenzhen Graduate School, and Hong Kong Baptist University (FRG 1/10-11/037). ",

year = "2011",

month = oct,

day = "7",

doi = "10.1021/ol2018246",

language = "English",

volume = "13",

pages = "5036--5039",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

AU - He, Shuzhong

AU - Li, Hongguang

AU - Yip, Yuk Wang

AU - Yeung, Chi Tung

AU - Fung, Yuen On

AU - Kong, Hoi Kuan

AU - Yeung, Ho Lun

AU - Law, Ga Lai

AU - Wong, Ka-Leung

AU - Lee, Chi Sing

AU - Lam, Michael Hon Wah

AU - Murphy, Margaret B.

AU - Lam, Paul Kwan Sing

AU - Wong, Wing Tak

N1 - This work was funded by grants from The Hong Kong Research Grants Council, the Hong Kong Polytechnic University (PolyU 503211P), City University of Hong Kong (CityU3/CRF/08), Peking University Shenzhen Graduate School, and Hong Kong Baptist University (FRG 1/10-11/037).

PY - 2011/10/7

Y1 - 2011/10/7

N2 - A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

AB - A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (KB= 6.1×104M-1) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption crosssection from 9 to 36 GM.

UR - https://www.scopus.com/pages/publications/84988043620

U2 - 10.1021/ol2018246

DO - 10.1021/ol2018246

M3 - Journal article

AN - SCOPUS:84988043620

SN - 1523-7060

VL - 13

SP - 5036

EP - 5039

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin

Abstract

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