Responsive luminescent lanthanide complexes for sensing pH, pO2 and hydrogencarbonate in competitive aqueous media

Thorri Gunnlaugsson; David Parker; J. A.Gareth Williams

doi:10.1117/12.347551

Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media

Thorri Gunnlaugsson^*
, David Parker
, J. A.Gareth Williams

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

2 Citations (Scopus)

Abstract

A series of chiral macrocyclic lanthanide complexes has been devised whose metal-based luminescence (Eu, Tb or Yb) is a function of a defined variable or set of variables. Complexes have been devised in which the lifetime or intensity of emission is a sensitive function of pH, pO₂, or halide ion concentration. The pH dependent systems report either the excited state singlet pK_a (Eu) or the triplet pK_a of an integral phenanthridinium chromophore, with luminescence enhancements of over 500. The halide and oxygen dependent systems operate differently via a quenching of the intermediate excited aryl singlet and triplet states respectively. In addition, complexes have been devised in which reversible binding of hydrogencarbonate displaces two bound water molecules, leading to an enhancement of the metal-based emission intensity (Eu, ΔJ = 2) or lifetime. At the same time, pronounced changes in the polarisation of emission occur, signalling changes in the helicity at the metal centre. Hydrogencarbonate chelates preferentially in the concentration range 20 to 40 mM in the presence of phosphate, lactate, citrate and halide at physiological levels.

Original language	English
Title of host publication	Advances in Fluorescence Sensing Technology IV
Editors	Joseph R. Lakowicz, Steven A. Soper, Richard B. Thompson
Publisher	SPIE
Pages	186-193
Number of pages	8
ISBN (Print)	0819430722
DOIs	https://doi.org/10.1117/12.347551
Publication status	Published - 3 May 1999
Event	BIOS '99: International Biomedical Optics Symposium - San Jose, United States Duration: 23 Jan 1999 → 29 Jan 1999 https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3602.toc (Conference proceedings)

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3602
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	BIOS '99: International Biomedical Optics Symposium
Country/Territory	United States
City	San Jose
Period	23/01/99 → 29/01/99
Internet address	https://www.spiedigitallibrary.org/conference-proceedings-of-spie/3602.toc (Conference proceedings)

Access to Document

10.1117/12.347551

Cite this

Gunnlaugsson, T., Parker, D., & Williams, J. A. G. (1999). Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media. In J. R. Lakowicz, S. A. Soper, & R. B. Thompson (Eds.), Advances in Fluorescence Sensing Technology IV (pp. 186-193). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 3602). SPIE. https://doi.org/10.1117/12.347551

Gunnlaugsson, Thorri ; Parker, David ; Williams, J. A.Gareth. / Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media. Advances in Fluorescence Sensing Technology IV. editor / Joseph R. Lakowicz ; Steven A. Soper ; Richard B. Thompson. SPIE, 1999. pp. 186-193 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Responsive luminescent lanthanide complexes for sensing pH, pO2 and hydrogencarbonate in competitive aqueous media",

abstract = "A series of chiral macrocyclic lanthanide complexes has been devised whose metal-based luminescence (Eu, Tb or Yb) is a function of a defined variable or set of variables. Complexes have been devised in which the lifetime or intensity of emission is a sensitive function of pH, pO2, or halide ion concentration. The pH dependent systems report either the excited state singlet pKa (Eu) or the triplet pKa of an integral phenanthridinium chromophore, with luminescence enhancements of over 500. The halide and oxygen dependent systems operate differently via a quenching of the intermediate excited aryl singlet and triplet states respectively. In addition, complexes have been devised in which reversible binding of hydrogencarbonate displaces two bound water molecules, leading to an enhancement of the metal-based emission intensity (Eu, ΔJ = 2) or lifetime. At the same time, pronounced changes in the polarisation of emission occur, signalling changes in the helicity at the metal centre. Hydrogencarbonate chelates preferentially in the concentration range 20 to 40 mM in the presence of phosphate, lactate, citrate and halide at physiological levels.",

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Gunnlaugsson, T, Parker, D & Williams, JAG 1999, Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media. in JR Lakowicz, SA Soper & RB Thompson (eds), Advances in Fluorescence Sensing Technology IV. Proceedings of SPIE - The International Society for Optical Engineering, vol. 3602, SPIE, pp. 186-193, BIOS '99: International Biomedical Optics Symposium, San Jose, California, United States, 23/01/99. https://doi.org/10.1117/12.347551

Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media. / Gunnlaugsson, Thorri; Parker, David; Williams, J. A.Gareth.
Advances in Fluorescence Sensing Technology IV. ed. / Joseph R. Lakowicz; Steven A. Soper; Richard B. Thompson. SPIE, 1999. p. 186-193 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 3602).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

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N2 - A series of chiral macrocyclic lanthanide complexes has been devised whose metal-based luminescence (Eu, Tb or Yb) is a function of a defined variable or set of variables. Complexes have been devised in which the lifetime or intensity of emission is a sensitive function of pH, pO2, or halide ion concentration. The pH dependent systems report either the excited state singlet pKa (Eu) or the triplet pKa of an integral phenanthridinium chromophore, with luminescence enhancements of over 500. The halide and oxygen dependent systems operate differently via a quenching of the intermediate excited aryl singlet and triplet states respectively. In addition, complexes have been devised in which reversible binding of hydrogencarbonate displaces two bound water molecules, leading to an enhancement of the metal-based emission intensity (Eu, ΔJ = 2) or lifetime. At the same time, pronounced changes in the polarisation of emission occur, signalling changes in the helicity at the metal centre. Hydrogencarbonate chelates preferentially in the concentration range 20 to 40 mM in the presence of phosphate, lactate, citrate and halide at physiological levels.

AB - A series of chiral macrocyclic lanthanide complexes has been devised whose metal-based luminescence (Eu, Tb or Yb) is a function of a defined variable or set of variables. Complexes have been devised in which the lifetime or intensity of emission is a sensitive function of pH, pO2, or halide ion concentration. The pH dependent systems report either the excited state singlet pKa (Eu) or the triplet pKa of an integral phenanthridinium chromophore, with luminescence enhancements of over 500. The halide and oxygen dependent systems operate differently via a quenching of the intermediate excited aryl singlet and triplet states respectively. In addition, complexes have been devised in which reversible binding of hydrogencarbonate displaces two bound water molecules, leading to an enhancement of the metal-based emission intensity (Eu, ΔJ = 2) or lifetime. At the same time, pronounced changes in the polarisation of emission occur, signalling changes in the helicity at the metal centre. Hydrogencarbonate chelates preferentially in the concentration range 20 to 40 mM in the presence of phosphate, lactate, citrate and halide at physiological levels.

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ER -

Gunnlaugsson T, Parker D, Williams JAG. Responsive luminescent lanthanide complexes for sensing pH, pO₂ and hydrogencarbonate in competitive aqueous media. In Lakowicz JR, Soper SA, Thompson RB, editors, Advances in Fluorescence Sensing Technology IV. SPIE. 1999. p. 186-193. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.347551