Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

Ga Lai Law; Robert Pal; Lars O. Palsson; David Parker; Ka Leung Wong

doi:10.1039/b920222f

Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

Ga Lai Law, Robert Pal, Lars O. Palsson, David Parker^*, Ka Leung Wong

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

113 Citations (Scopus)

Abstract

A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (_em 12%), allowing the creation of a ratiometric sensory system for pO₂ (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

Original language	English
Pages (from-to)	7321-7323
Number of pages	3
Journal	Chemical Communications
Issue number	47
Early online date	2 Nov 2009
DOIs	https://doi.org/10.1039/b920222f
Publication status	Published - 21 Dec 2009

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10.1039/b920222f

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title = "Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing",

abstract = "A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (em 12%), allowing the creation of a ratiometric sensory system for pO2 (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.",

author = "Law, {Ga Lai} and Robert Pal and Palsson, {Lars O.} and David Parker and Wong, {Ka Leung}",

note = "We thank EPSRC and the Royal Society for support Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2009",

year = "2009",

month = dec,

day = "21",

doi = "10.1039/b920222f",

language = "English",

pages = "7321--7323",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing. / Law, Ga Lai; Pal, Robert; Palsson, Lars O. et al.
In: Chemical Communications, No. 47, 21.12.2009, p. 7321-7323.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group

T2 - Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

AU - Law, Ga Lai

AU - Pal, Robert

AU - Palsson, Lars O.

AU - Parker, David

AU - Wong, Ka Leung

PY - 2009/12/21

Y1 - 2009/12/21

N2 - A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (em 12%), allowing the creation of a ratiometric sensory system for pO2 (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

AB - A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (em 12%), allowing the creation of a ratiometric sensory system for pO2 (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

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UR - https://pubs.rsc.org/en/content/articlelanding/2009/cc/b920222f

U2 - 10.1039/b920222f

DO - 10.1039/b920222f

M3 - Journal article

C2 - 20024215

AN - SCOPUS:72649102984

SN - 1359-7345

SP - 7321

EP - 7323

JO - Chemical Communications

JF - Chemical Communications

IS - 47

ER -

Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: Applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

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