Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

Hanzhong Ke; Hongda Wang; Rick W K WONG; Nai Ki MAK; Daniel W J KWONG; Ka-Leung WONG; Hoi Lam TAM

doi:10.1039/c0cc01848a

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

Hanzhong Ke
, Hongda Wang
, Rick W K WONG^*
, Nai Ki MAK
, Daniel W J KWONG
, Ka-Leung WONG
, Hoi Lam TAM

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

61 Citations (Scopus)

Abstract

A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Φ_Δ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

Original language	English
Pages (from-to)	6678-6680
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	36
DOIs	https://doi.org/10.1039/c0cc01848a
Publication status	Published - 28 Sept 2010

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title = "Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing",

abstract = "A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.",

author = "Hanzhong Ke and Hongda Wang and WONG, \{Rick W K\} and MAK, \{Nai Ki\} and KWONG, \{Daniel W J\} and Ka-Leung WONG and TAM, \{Hoi Lam\}",

note = "The work described in this paper was partially supported by grants from the Research Grants Council of the Hong Kong SAR, P. R. China (HKBU 202308 and HKBU 202509) and a grant from the Hong Kong Baptist University (FRG2/08-09/067).",

year = "2010",

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doi = "10.1039/c0cc01848a",

language = "English",

volume = "46",

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journal = "Chemical Communications",

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T1 - Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications

T2 - Two-photon (near-infrared) induced imaging and regioselective cell killing

AU - Ke, Hanzhong

AU - Wang, Hongda

AU - WONG, Rick W K

AU - MAK, Nai Ki

AU - KWONG, Daniel W J

AU - WONG, Ka-Leung

AU - TAM, Hoi Lam

N1 - The work described in this paper was partially supported by grants from the Research Grants Council of the Hong Kong SAR, P. R. China (HKBU 202308 and HKBU 202509) and a grant from the Hong Kong Baptist University (FRG2/08-09/067).

PY - 2010/9/28

Y1 - 2010/9/28

N2 - A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

AB - A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

UR - https://www.scopus.com/pages/publications/77956314448

U2 - 10.1039/c0cc01848a

DO - 10.1039/c0cc01848a

M3 - Journal article

C2 - 20717606

AN - SCOPUS:77956314448

SN - 1359-7345

VL - 46

SP - 6678

EP - 6680

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

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