Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

Hanzhong Ke; Hongda Wang; Rick W K WONG; Nai Ki MAK; Daniel W J KWONG; Ka-Leung WONG; Hoi Lam TAM

doi:10.1039/c0cc01848a

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

Hanzhong Ke, Hongda Wang, Rick W K WONG^*, Nai Ki MAK, Daniel W J KWONG, Ka-Leung WONG, Hoi Lam TAM

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Φ_Δ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

Original language	English
Pages (from-to)	6678-6680
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	36
DOIs	https://doi.org/10.1039/c0cc01848a
Publication status	Published - 28 Sept 2010

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc01848a

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title = "Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing",

abstract = "A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.",

author = "Hanzhong Ke and Hongda Wang and WONG, {Rick W K} and MAK, {Nai Ki} and KWONG, {Daniel W J} and Ka-Leung WONG and TAM, {Hoi Lam}",

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AU - Ke, Hanzhong

AU - Wang, Hongda

AU - WONG, Rick W K

AU - MAK, Nai Ki

AU - KWONG, Daniel W J

AU - WONG, Ka-Leung

AU - TAM, Hoi Lam

PY - 2010/9/28

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AB - A mitochondria-permeable ruthenium(ii) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (ΦΔ = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

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DO - 10.1039/c0cc01848a

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AN - SCOPUS:77956314448

SN - 1359-7345

VL - 46

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JO - Chemical Communications

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Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: Two-photon (near-infrared) induced imaging and regioselective cell killing

Abstract

Scopus Subject Areas

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