Response and adaptation of bone cells to simulated microgravity

Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge ZHANG, Peng Shang, Airong Qian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Bone loss induced by microgravity during space flight is one of the most deleterious factors on astronaut's health and is mainly attributed to an unbalance in the process of bone remodeling. Studies from the space microgravity have demonstrated that the disruption of bone remodeling is associated with the changes of four main functional bone cells, including osteoblast, osteoclast, osteocyte, and mesenchymal stem cells. For the limited availability, expensive costs and confined experiment conditions for conducting space microgravity studies, the mechanism of bone cells response and adaptation to microgravity is still unclear. Therefore, some ground-based simulated microgravity methods have been developed to investigate the bioeffects of microgravity and the mechanisms. Here, based on our studies and others, we review how bone cells (osteoblasts, osteoclasts, osteocytes and mesenchymal stem cells) respond and adapt to simulated microgravity.

Original languageEnglish
Pages (from-to)396-408
Number of pages13
JournalActa Astronautica
Volume104
Issue number1
DOIs
Publication statusPublished - Nov 2014

Scopus Subject Areas

  • Aerospace Engineering

User-Defined Keywords

  • Bone cells
  • Bone loss
  • Mechanical sensitive molecules
  • Signaling pathways
  • Simulated microgravity

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