Research trends and prospects on brain metastasis from breast cancer: A bibliometric analysis

Si Qi Wu, Yan Liu, Jie Zhou, Yan Ting You, Xing Hong Zhou, Li Qian Chen, Hiu Yee Kwan, Xiao Shan Zhao*, Yi Fen Wu*, Yan Yan Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review


Introduction: Brain metastasis is the terminal event of breast cancer with poor prognoses. Therefore, this article aimed to provide an updated summary on the development, hotspots, and research trends of brain metastasis from breast cancer based on bibliometric analysis.

Method: Publications on breast cancer with brain metastasis retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, and other online bibliometric analysis platforms were used to analyze and visualize the result.

Result: In totality, 693 researchers from 3,623 institutions across 74 counties and regions published a total of 2,790 papers in 607 journals. There was a noticeable increase in publications in 2006. The United States was the dominant country with the most publications followed by China. University Texas MD Anderson Cancer Center was the most productive institution, while Dana Farber Cancer Institution was the most cited. Journal of Neuro-Oncology published the most papers, while Journal of Clinical Oncology ranked first based on cocited analysis. Nancy U. Lin was the most productive and cited author with high influence. There was a focus on basic research, clinical trials, local therapy, treatment optimization, and epidemiological studies regarding brain metastases from breast cancer. References focused on pathogenesis, prevention, treatment, and prognosis were cited most frequently, among which the clinical trial of novel treatment attracted most attention from researchers. Reference citation burst detection suggested that new therapies such as the novel tyrosine kinase inhibitor and antibody–drug conjugate may lead the research trends in the future.

Conclusion: High-income countries contributed more to the field of breast cancer with brain metastasis, while developing countries like China developed quickly. Furthermore, the success of novel therapies in recent years may lead to the new era of treatment of breast cancer with brain metastasis in the future.

Original languageEnglish
Article number1091249
Number of pages13
JournalFrontiers in Oncology
Publication statusPublished - 5 Apr 2023

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • ADC (antibody-drug conjugate)
  • bibliometric analysis
  • brain metastasis
  • breast cancer
  • research trend
  • TKI (tyrosine kinase inhibitor)


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