TY - JOUR
T1 - Repeated Measurements of Paraben Exposure during Pregnancy in Relation to Fetal and Early Childhood Growth
AU - Wu, Chuansha
AU - Xia, Wei
AU - Li, Yuanyuan
AU - Li, Jiufeng
AU - Zhang, Bin
AU - Zheng, Tongzhang
AU - Zhou, Aifen
AU - Zhao, Hongzhi
AU - Huo, Wenqian
AU - Hu, Jie
AU - Jiang, Minmin
AU - Hu, Chen
AU - Liao, Jiaqiang
AU - Chen, Xi
AU - Xu, Bing
AU - Lu, Shi
AU - Cai, Zongwei
AU - Xu, Shunqing
N1 - Funding Information:
We thank all the participants and collaborators for their great efforts in the cohort study. This work was supported by the National Natural Science Foundation of China (21437002, 91643207, 81372959, and 81402649), and the National Key Research and Development Plan of China (2016YFC0206203 and 2016YFC0206700), and the Fundamental Research Funds for the Central Universities, HUST (2016YXZD043).
Publisher copyright:
© 2018 American Chemical Society
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Parabens are potential endocrine disruptors with short half-lives in the human body. To date, few epidemiological studies regarding repeated paraben measurements during pregnancy associated with fetal and childhood growth have been conducted. Within a Chinese prenatal cohort, 850 mother-infant pairs from whom a complete set of maternal urine samples were acquired during three trimesters were included, and the levels of five parabens were measured. We assessed the associations of both average and trimester-specific urinary paraben levels with weight and height z-scores at birth, 6 months, 1, and 2 years of age. In all infants, each doubling increase in average ethyl paraben (EtP) was associated with -2.82% (95% CI: -5.11%, -0.53%) decrease in weight z-score at birth, whereas no significant age-specific associations were identified. After stratifying by sex, we further observed age-specific association of average EtP with -3.96% (95% CI: -7.03%, -0.89%) and -3.38% (95% CI: 6.72%, -0.03%) reduction in weight z-scores at 1 and 2 years in males, respectively. Third-trimester EtP was negatively associated with weight z-scores at birth, 1 and 2 years in males. Our results suggested negative associations between prenatal paraben exposure and fetal and childhood growth, and the third trimester may be the window of susceptibility.
AB - Parabens are potential endocrine disruptors with short half-lives in the human body. To date, few epidemiological studies regarding repeated paraben measurements during pregnancy associated with fetal and childhood growth have been conducted. Within a Chinese prenatal cohort, 850 mother-infant pairs from whom a complete set of maternal urine samples were acquired during three trimesters were included, and the levels of five parabens were measured. We assessed the associations of both average and trimester-specific urinary paraben levels with weight and height z-scores at birth, 6 months, 1, and 2 years of age. In all infants, each doubling increase in average ethyl paraben (EtP) was associated with -2.82% (95% CI: -5.11%, -0.53%) decrease in weight z-score at birth, whereas no significant age-specific associations were identified. After stratifying by sex, we further observed age-specific association of average EtP with -3.96% (95% CI: -7.03%, -0.89%) and -3.38% (95% CI: 6.72%, -0.03%) reduction in weight z-scores at 1 and 2 years in males, respectively. Third-trimester EtP was negatively associated with weight z-scores at birth, 1 and 2 years in males. Our results suggested negative associations between prenatal paraben exposure and fetal and childhood growth, and the third trimester may be the window of susceptibility.
UR - http://www.scopus.com/inward/record.url?scp=85059649010&partnerID=8YFLogxK
U2 - 10.1021/acs.est.8b01857
DO - 10.1021/acs.est.8b01857
M3 - Journal article
C2 - 30427191
AN - SCOPUS:85059649010
SN - 0013-936X
VL - 53
SP - 422
EP - 433
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 1
ER -