Regulation of TRP channels by phosphorylation

Xiaoqiang Yao*, Hiu Yee Kwan, Yu Huang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

63 Citations (Scopus)

Abstract

The transient receptor potential (TRP) channels are a group of Ca 2+-permeable cation channels (except TRPM4 and TRPM5) that function as cellular sensors of various internal and external stimuli. Most of these channels are expressed in the nervous system and they play a key role in sensory physiology. They may respond to temperature, pressure, inflammatory agents, pain, osmolarity, taste and many other stimuli. Recent development indicates that the activity of these channels is regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalNeuroSignals
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2006

Scopus Subject Areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

User-Defined Keywords

  • Ca2+ influx
  • Phosphorylation
  • TRP channels

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