Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase

Jianming Li*, Kyoung Hee Nam

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

524 Citations (Scopus)


GSK3/SHAGGY is a highly conserved serine/threonine kinase implicated in many signaling pathways in eukaryotes. Although many GSK3/SHAGGY-like kinases have been identified in plants, little is known about their functions in plant growth and development. Here we show that the Arabidopsis BRASSINOSTEROID-INSENSITIVE 2 (BIN2) gene encodes a GSK3/SHAGGY-like kinase. Gain-of-function mutations within its coding sequence or its overexpression inhibit brassinosteroid (BR) signaling, resulting in plants that resemble BR-deficient and BR-response mutants. In contrast, reduced BIN2 expression via cosuppression partially rescues a weak BR-signaling mutation. Thus, BIN2 acts as a negative regulator to control steroid signaling in plants.

Original languageEnglish
Pages (from-to)1299-1301
Number of pages3
Issue number5558
Publication statusPublished - 15 Feb 2002

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