Red/Near-Infrared Emissive Metalloporphyrin-Based Nanodots for Magnetic Resonance Imaging-Guided Photodynamic Therapy In Vivo

Fengshou Wu, Jingwen Chen, Zhicong Li, Huifang Su*, Ken C F LEUNG, Han Wang, Xunjin ZHU

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Near-infrared emissive (NIR) porphyrin-implanted carbon nanodots (PCNDs or MPCNDs) are prepared by selectively carbonization of free base or metal complexes [M = Zn(II) or Mn(III)] of tetra-(meso-aminophenyl)porphyrin in the presence of citric acid. The as-prepared nanodots exhibit spontaneously NIR emission, small size, good aqueous dispersibility, and favorable biocompatibility characteristic of both porphyrins and pristine carbon nanodots. The subcellular localization experiment of nanodots indicates a lysosome-targeting feature. And the in vitro photodynamic therapy (PDT) results on HeLa cells indicate the nanodots alone have no adverse effect on tumor cells, but display remarkable photodynamic efficacy upon irradiation. Moreover, MnPCNDs containing paramagnetic Mn(III) ions, which possesses good biocompatibility, NIR luminescence, and magnetic resonance imaging and efficient singlet oxygen production, are further studied in magnetic resonance imaging-guided photodynamic therapy in vivo.

Original languageEnglish
Article number1800208
JournalParticle and Particle Systems Characterization
Volume35
Issue number9
DOIs
Publication statusPublished - Sep 2018

Scopus Subject Areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

User-Defined Keywords

  • magnetic resonance imaging
  • nanodots
  • near-infrared
  • photodynamic therapy
  • porphyrin

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