TY - JOUR
T1 - Red/Near-Infrared Emissive Metalloporphyrin-Based Nanodots for Magnetic Resonance Imaging-Guided Photodynamic Therapy In Vivo
AU - Wu, Fengshou
AU - Chen, Jingwen
AU - Li, Zhicong
AU - Su, Huifang
AU - LEUNG, Ken C F
AU - Wang, Han
AU - ZHU, Xunjin
N1 - Funding Information:
F.S.W., J.W.C., and Z.C.L. contributed equally to this work. The authors thank National Natural Science Foundation of China (21601142 and 81671740), Natural Science Foundation of Hubei Province (2017CFB689), and Hong Kong Research Grants Council (HKBU 22304115). H.W. thanks the National Key Research and Development Program of China (2016YFC0107108), the Gaofeng Clinical Medicine Grant of Shanghai Municipal Education Commission (20152230), and the Shanghai Academic/Technology Research Leader Program (17XD1424200). X.Z. also thanks the financial support (FRG2/14-15/034, FRG1/14-15/058, RC-ICRS/15-16/02E and RC-ICRS/1617/02C-CHE) from the Research Committee of the Hong Kong Baptist University. All experiments related to live subjects were performed in compliance with the relevant laws and guidelines of Shanghai General Hospital, and the ethical committee of Shanghai General Hospital has approved the experiments.
PY - 2018/9
Y1 - 2018/9
N2 - Near-infrared emissive (NIR) porphyrin-implanted carbon nanodots (PCNDs or MPCNDs) are prepared by selectively carbonization of free base or metal complexes [M = Zn(II) or Mn(III)] of tetra-(meso-aminophenyl)porphyrin in the presence of citric acid. The as-prepared nanodots exhibit spontaneously NIR emission, small size, good aqueous dispersibility, and favorable biocompatibility characteristic of both porphyrins and pristine carbon nanodots. The subcellular localization experiment of nanodots indicates a lysosome-targeting feature. And the in vitro photodynamic therapy (PDT) results on HeLa cells indicate the nanodots alone have no adverse effect on tumor cells, but display remarkable photodynamic efficacy upon irradiation. Moreover, MnPCNDs containing paramagnetic Mn(III) ions, which possesses good biocompatibility, NIR luminescence, and magnetic resonance imaging and efficient singlet oxygen production, are further studied in magnetic resonance imaging-guided photodynamic therapy in vivo.
AB - Near-infrared emissive (NIR) porphyrin-implanted carbon nanodots (PCNDs or MPCNDs) are prepared by selectively carbonization of free base or metal complexes [M = Zn(II) or Mn(III)] of tetra-(meso-aminophenyl)porphyrin in the presence of citric acid. The as-prepared nanodots exhibit spontaneously NIR emission, small size, good aqueous dispersibility, and favorable biocompatibility characteristic of both porphyrins and pristine carbon nanodots. The subcellular localization experiment of nanodots indicates a lysosome-targeting feature. And the in vitro photodynamic therapy (PDT) results on HeLa cells indicate the nanodots alone have no adverse effect on tumor cells, but display remarkable photodynamic efficacy upon irradiation. Moreover, MnPCNDs containing paramagnetic Mn(III) ions, which possesses good biocompatibility, NIR luminescence, and magnetic resonance imaging and efficient singlet oxygen production, are further studied in magnetic resonance imaging-guided photodynamic therapy in vivo.
KW - magnetic resonance imaging
KW - nanodots
KW - near-infrared
KW - photodynamic therapy
KW - porphyrin
UR - http://www.scopus.com/inward/record.url?scp=85052492015&partnerID=8YFLogxK
U2 - 10.1002/ppsc.201800208
DO - 10.1002/ppsc.201800208
M3 - Journal article
AN - SCOPUS:85052492015
SN - 0934-0866
VL - 35
JO - Particle and Particle Systems Characterization
JF - Particle and Particle Systems Characterization
IS - 9
M1 - 1800208
ER -