Reconstructing dynamic gene regulatory network for the development process of hepatocellular carcinoma

Hailong ZHU*, R. Shyama Prasad Rao, Luonan Chen

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference proceedingpeer-review

1 Citation (Scopus)

Abstract

A crucial work of investigating the mechanisms of cancer development is to unraveling the dynamic nature of gene regulation during the disease process. However, reconstruction of dynamic gene regulatory network requires time-sequence samples of a biological process, which are not available for many bio-medical problems. In this paper, we propose a dynamic cascaded method to reconstruct dynamic gene networks from sample-based transcriptional data. Our method is based on two biologically plausible assumptions, which can characterise the dynamic and continuous nature of gene transcription. Our approach was successfully applied to reconstruct the dynamic gene networks of hepatocellular carcinoma (HCC) progression. The derived HCC networks were verified by functional analysis and network enrichment analysis.

Original languageEnglish
Title of host publicationProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Pages159-165
Number of pages7
DOIs
Publication statusPublished - 2012
Event2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 - Philadelphia, PA, United States
Duration: 4 Oct 20127 Oct 2012

Publication series

NameProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

Conference

Conference2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Country/TerritoryUnited States
CityPhiladelphia, PA
Period4/10/127/10/12

Scopus Subject Areas

  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • dynamic network
  • Gene regulatory network
  • Herpatocellulur Carcinoma
  • sample-based transcriptional data

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