TY - GEN
T1 - Reconstructing dynamic gene regulatory network for the development process of hepatocellular carcinoma
AU - Zhu, Hailong
AU - Rao, R. Shyama Prasad
AU - Chen, Luonan
PY - 2012
Y1 - 2012
N2 - A crucial work of investigating the mechanisms of cancer development is to unraveling the dynamic nature of gene regulation during the disease process. However, reconstruction of dynamic gene regulatory network requires time-sequence samples of a biological process, which are not available for many bio-medical problems. In this paper, we propose a dynamic cascaded method to reconstruct dynamic gene networks from sample-based transcriptional data. Our method is based on two biologically plausible assumptions, which can characterise the dynamic and continuous nature of gene transcription. Our approach was successfully applied to reconstruct the dynamic gene networks of hepatocellular carcinoma (HCC) progression. The derived HCC networks were verified by functional analysis and network enrichment analysis.
AB - A crucial work of investigating the mechanisms of cancer development is to unraveling the dynamic nature of gene regulation during the disease process. However, reconstruction of dynamic gene regulatory network requires time-sequence samples of a biological process, which are not available for many bio-medical problems. In this paper, we propose a dynamic cascaded method to reconstruct dynamic gene networks from sample-based transcriptional data. Our method is based on two biologically plausible assumptions, which can characterise the dynamic and continuous nature of gene transcription. Our approach was successfully applied to reconstruct the dynamic gene networks of hepatocellular carcinoma (HCC) progression. The derived HCC networks were verified by functional analysis and network enrichment analysis.
KW - dynamic network
KW - Gene regulatory network
KW - Herpatocellulur Carcinoma
KW - sample-based transcriptional data
UR - http://www.scopus.com/inward/record.url?scp=84875592916&partnerID=8YFLogxK
U2 - 10.1109/BIBMW.2012.6470298
DO - 10.1109/BIBMW.2012.6470298
M3 - Conference proceeding
AN - SCOPUS:84875592916
SN - 9781467327466
T3 - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
SP - 159
EP - 165
BT - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
T2 - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Y2 - 4 October 2012 through 7 October 2012
ER -