Receptors of glutamate and neurotrophin in vestibular neuronal functions

Y. S. Chan*, L. W. Chen, C. H. Lai, D. K.Y. Shum, Kin Lam YUNG, F. X. Zhang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

The last decade has witnessed advances in understanding the roles of receptors of neurotrophin and glutamate in the vestibular system. In the first section of this review, the biological actions of neurotrophins and their receptors in the peripheral and central vestibular systems are summarized. Emphasis will be placed on the roles of neurotrophins in developmental plasticity and in the maintenance of vestibular function in the adult animal. This is reviewed in relation to the developmental expression pattern of neurotrophins and their receptors within the vestibular nuclei. The second part is focused on the functional role of different glutamate receptors on central vestibular neurons. The developmental expression pattern of glutamate receptor subunits within the vestibular nuclei is reviewed in relation to the potential role of glutamate receptors in regulating the development of vestibular function.

Original languageEnglish
Pages (from-to)577-587
Number of pages11
JournalJournal of Biomedical Science
Volume10
Issue number6
DOIs
Publication statusPublished - 2003

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

User-Defined Keywords

  • Glutamate receptor
  • Neurotrophin receptor
  • Vestibular function

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