Recent two-year advances in anti-dengue small-molecule inhibitors

Chao Yang; Wansheng Xie; Heqian Zhang; Wenjian Xie; Tiantian Tian; Zhiwei Qin

doi:10.1016/j.ejmech.2022.114753

Recent two-year advances in anti-dengue small-molecule inhibitors

Chao Yang, Wansheng Xie, Heqian Zhang, Wenjian Xie, Tiantian Tian^*, Zhiwei Qin^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

5 Citations (Scopus)

Abstract

Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.

Original language	English
Article number	114753
Number of pages	11
Journal	European Journal of Medicinal Chemistry
Volume	243
DOIs	https://doi.org/10.1016/j.ejmech.2022.114753
Publication status	Published - 5 Dec 2022

User-Defined Keywords

Aedes aegypti
Dengue fever
Flaviviruses
Inhibitors
Tropical diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2022.114753

Cite this

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title = "Recent two-year advances in anti-dengue small-molecule inhibitors",

abstract = "Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.",

keywords = "Aedes aegypti, Dengue fever, Flaviviruses, Inhibitors, Tropical diseases",

author = "Chao Yang and Wansheng Xie and Heqian Zhang and Wenjian Xie and Tiantian Tian and Zhiwei Qin",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (32170079), the Natural Science Foundation of Guangdong (2021A1515012026), and Beijing Normal University via the Youth Talent Strategic Program Project (310432104). Publisher Copyright: {\textcopyright} 2022 Elsevier Masson SAS. All rights reserved.",

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AU - Yang, Chao

AU - Xie, Wansheng

AU - Zhang, Heqian

AU - Xie, Wenjian

AU - Tian, Tiantian

AU - Qin, Zhiwei

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (32170079), the Natural Science Foundation of Guangdong (2021A1515012026), and Beijing Normal University via the Youth Talent Strategic Program Project (310432104). Publisher Copyright: © 2022 Elsevier Masson SAS. All rights reserved.

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Y1 - 2022/12/5

N2 - Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.

AB - Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.

KW - Aedes aegypti

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KW - Inhibitors

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JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 114753

ER -

Recent two-year advances in anti-dengue small-molecule inhibitors

Abstract

User-Defined Keywords

UN SDGs

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