Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

Shuaijian Ni, Zhenjian Zhuo, Yufei Pan, Yuanyuan YU, Fangfei LI, Jin LIU, Luyao Wang, Xiaoqiu Wu, Dijie Li, Youyang Wan, Lihe Zhang, Zhenjun Yang, Bao Ting Zhang, Aiping LYU*, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Aptamers are oligonucleotide sequences with a length of about 25-80 bases which have abilities to bind to specific target molecules that rival those of monoclonal antibodies. They are attracting great attention in diverse clinical translations on account of their various advantages, including prolonged storage life, little batch-to-batch differences, very low immunogenicity, and feasibility of chemical modifications for enhancing stability, prolonging the half-life in serum, and targeted delivery. In this Review, we demonstrate the emerging aptamer discovery technologies in developing advanced techniques for producing aptamers with high performance consistently and efficiently as well as requiring less cost and resources but offering a great chance of success. Further, the diverse modifications of aptamers for therapeutic applications including therapeutic agents, aptamer-drug conjugates, and targeted delivery materials are comprehensively summarized.

Original languageEnglish
Pages (from-to)9500-9519
Number of pages20
JournalACS applied materials & interfaces
Volume13
Issue number8
DOIs
Publication statusPublished - 3 Mar 2021

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • aptamer
  • aptamer-drug conjugate (ApDC)
  • long-acting modification
  • microfluidic SELEX
  • nanoparticle
  • targeted delivery materials
  • therapeutic application

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