Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

Sang Cuo Nao, Ke Jia Wu, Wanhe Wang, Chung Hang Leung*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches.

Original languageEnglish
Article number767
JournalFrontiers in Chemistry
Volume8
DOIs
Publication statusPublished - 1 Sep 2020

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • aptamer
  • food safety
  • G-quadruplex
  • nucleic acid detection
  • ochratoxin A

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