Recent developments in microfluidics for cell studies

Bin Xiong, Kangning REN, Yiwei Shu, Yin Chen, Bo Shen, Hongkai Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

As a technique for precisely manipulating fluid at the micrometer scale, the field of microfluidics has experienced an explosive growth over the past two decades, particularly owing to the advances in device design and fabrication. With the inherent advantages associated with its scale of operation, and its flexibility in being incorporated with other microscale techniques for manipulation and detection, microfluidics has become a major enabling technology, which has introduced new paradigms in various fields involving biological cells. A microfluidic device is able to realize functions that are not easily imaginable in conventional biological analysis, such as highly parallel, sophisticated high-throughput analysis, single-cell analysis in a well-defined manner, and tissue engineering with the capability of manipulation at the single-cell level. Major advancements in microfluidic device fabrication and the growing trend of implementing microfluidics in cell studies are presented, with a focus on biological research and clinical diagnostics.

Original languageEnglish
Pages (from-to)5525-5532
Number of pages8
JournalAdvanced Materials
Volume26
Issue number31
DOIs
Publication statusPublished - 20 Aug 2014

Scopus Subject Areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

User-Defined Keywords

  • biomedical applications
  • diagnostics
  • microfluidics
  • single-cell analysis
  • tissue engineering

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