Recent Developments in G-Quadruplex Probes

  • Dik Lung Ma*
  • , Zhihong Zhang
  • , Modi Wang
  • , Lihua Lu
  • , Hai Jing Zhong
  • , Chung Hang Leung
  • *Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

171 Citations (Scopus)

Abstract

Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.

Original languageEnglish
Article number3087
Pages (from-to)812-828
Number of pages17
JournalChemistry and Biology
Volume22
Issue number7
DOIs
Publication statusPublished - 24 Jul 2015

Fingerprint

Dive into the research topics of 'Recent Developments in G-Quadruplex Probes'. Together they form a unique fingerprint.

Cite this