Recent Developments in G-Quadruplex Probes

Edmond Dik Lung MA*, Zhihong Zhang, Modi Wang, Lihua Lu, Hai Jing Zhong, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

158 Citations (Scopus)


Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.

Original languageEnglish
Article number3087
Pages (from-to)812-828
Number of pages17
JournalChemistry and Biology
Issue number7
Publication statusPublished - 24 Jul 2015

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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