Recent Developments in G-Quadruplex Probes

Edmond Dik Lung MA; Zhihong Zhang; Modi Wang; Lihua Lu; Hai Jing Zhong; Chung Hang Leung

doi:10.1016/j.chembiol.2015.06.016

Recent Developments in G-Quadruplex Probes

Edmond Dik Lung MA^*, Zhihong Zhang, Modi Wang, Lihua Lu, Hai Jing Zhong, Chung Hang Leung

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

152 Citations (Scopus)

Abstract

Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.

Original language	English
Article number	3087
Pages (from-to)	812-828
Number of pages	17
Journal	Chemistry and Biology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/j.chembiol.2015.06.016
Publication status	Published - 24 Jul 2015

Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2015.06.016

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title = "Recent Developments in G-Quadruplex Probes",

abstract = "Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.",

author = "MA, {Edmond Dik Lung} and Zhihong Zhang and Modi Wang and Lihua Lu and Zhong, {Hai Jing} and Leung, {Chung Hang}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (ANR-HKBU201/12), Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP- 14-15-P001), the Science and Technology Development Fund, Macao SAR (103/2012/A3 and 098/2014/A2), the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).",

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AU - Leung, Chung Hang

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (ANR-HKBU201/12), Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP- 14-15-P001), the Science and Technology Development Fund, Macao SAR (103/2012/A3 and 098/2014/A2), the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).

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Recent Developments in G-Quadruplex Probes

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