@article{49950169aa274916a18cb367d832adcc,
title = "Recent development of transition metal complexes with in vivo antitumor activity",
abstract = "The often severe side effects displayed by currently used platinum and ruthenium complexes have motivated researchers to design and develop transition metal-based anti-tumor agents with reduced toxicity. Distinct from organic anti-tumor drugs, transition metal complexes possess several properties that render them as promising scaffolds for anti-cancer drug discovery. While a vast number of metal complexes have been synthesized and reported to be promising and potent in vitro anticancer active compounds, fewer have shown efficacy in in vivo models. The demonstration of in vivo potency is an essential step for lead candidates for clinical trials. In this review, we highlight examples of transition metal-based complexes that have shown in vivo anti-tumor activities that have been described in recent years.",
keywords = "Anti-tumor, Cancer, In vivo, Transition metal",
author = "Liang, {Jia Xin} and Zhong, {Hai Jing} and Guanjun Yang and Kasipandi Vellaisamy and Ma, {Dik Lung} and Leung, {Chung Hang}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612, and HKBU/201913), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the State Key Laboratory of Synthetic Chemistry, the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS), and National Natural Science Foundation of China (21628502). Publisher copyright: {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = dec,
doi = "10.1016/j.jinorgbio.2017.06.002",
language = "English",
volume = "177",
pages = "276--286",
journal = "Journal of Inorganic Biochemistry",
issn = "0162-0134",
publisher = "Elsevier Inc.",
}